{"entity":{"id":"chemoradiation","kind":"term","name":"Chemoradiation (chemoradiotherapy, CRT)","aka":["chemoradiotherapy","chemo-radiotherapy","chemoradiation","definitive chemoradiation","concurrent chemoradiation","concurrent chemoradiotherapy","sequential chemoradiation","radiochemotherapy","trimodality therapy","trimodality","bimodality"],"tldr":"Radiotherapy given at the same time as chemotherapy, which sensitises the cancer to radiation. It is the curative treatment for cervical, anal, laryngeal and oropharyngeal cancers, stage III lung cancer and glioblastoma, and is given before surgery in oesophageal and rectal cancer, at the cost of more acute mouth and gullet inflammation.","summary":"Concurrent chemoradiation (usually with cisplatin, or 5-FU and mitomycin, or carboplatin-paclitaxel) is definitive treatment for cervical, anal, laryngeal and oropharyngeal cancers, stage III lung cancer (followed by durvalumab, PACIFIC), glioblastoma (with temozolomide) and bladder preservation (trimodality with TURBT), and is preoperative in oesophageal (CROSS) and rectal cancer. Concurrent beats sequential in most comparisons at the cost of more acute toxicity (mucositis, oesophagitis). Chemotherapy acts as a radiosensitiser rather than for its own systemic effect, so doses are lower than in systemic regimens.","asOf":"2026-09-09","wikipedia":"https://en.wikipedia.org/wiki/Chemoradiotherapy","links":[{"label":"Wikipedia","url":"https://en.wikipedia.org/wiki/Chemoradiotherapy"}],"tags":[],"related":["organ-preservation","imrt-term","mucositis"],"cancers":["cervical","head-and-neck","nsclc","esophageal","glioblastoma","urothelial"],"sections":["radiation","chemotherapy"],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":["pacific","cross"],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"category":"Treatment jargon"},"route":"/terms/chemoradiation/","neighbours":{"term":[{"id":"abdominoperineal-resection","kind":"term","name":"Abdominoperineal resection","route":"/terms/abdominoperineal-resection/"},{"id":"consolidation-therapy","kind":"term","name":"Consolidation 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