{"entity":{"id":"chd7","kind":"target","name":"CHD7","aka":["chromodomain helicase DNA binding protein 7","ATP-dependent chromatin remodeler CHD7","KIAA1416","FLJ20357","FLJ20361"],"tldr":"CHD7 (ATP-dependent chromatin remodeler CHD7) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Medulloblastoma.","summary":"ATP-dependent chromatin-remodeling factor, slides nucleosomes along DNA; nucleosome sliding requires ATP. Probable transcription regulator. May be involved in the in 45S precursor rRNA production.\n\nIntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Medulloblastoma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:20626","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:20626"},{"label":"UniProt Q9P2D1","url":"https://www.uniprot.org/uniprotkb/Q9P2D1/entry"},{"label":"NCBI Gene 55636","url":"https://www.ncbi.nlm.nih.gov/gene/55636"},{"label":"Ensembl ENSG00000171316","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000171316"}],"tags":["cancer-genes-wave"],"related":["intogen"],"cancers":["medulloblastoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 1 cohort. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"CHD7","role":["tumour-suppressor"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:20626","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:20626","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q9P2D1","url":"https://www.uniprot.org/uniprotkb/Q9P2D1/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"IntOGen CHD7","url":"https://www.intogen.org/search?gene=CHD7","note":"driver in 1 cohort (Act 0, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"specificitySources":[],"hgnc":"HGNC:20626","ensembl":"ENSG00000171316","uniprot":"Q9P2D1","entrez":"55636","firstDescribed":2000,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: Nagase et al, DNA Res, 2000, \"Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro\".","firstDescribedSource":"https://pubmed.ncbi.nlm.nih.gov/10718198/","biology":"ATP-dependent chromatin-remodeling factor, slides nucleosomes along DNA; nucleosome sliding requires ATP. Probable transcription regulator. May be involved in the in 45S precursor rRNA production. Location: Nucleus; Nucleus, nucleolus (UniProt). Locus 8q12.2 (HGNC).","whereFound":["Medulloblastoma: IntOGen driver in 1 cohort (MBL)"],"targetClass":"tumor-suppressor","prevalence":[]},"route":"/targets/chd7/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"}],"cancer":[{"id":"medulloblastoma","kind":"cancer","name":"Medulloblastoma","route":"/cancers/medulloblastoma/"}]}}