{"entity":{"id":"charlotte-coles","kind":"person","name":"Charlotte E. Coles","aka":[],"tldr":"Led IMPORT LOW, which showed partial-breast radiotherapy is as effective as whole-breast treatment with fewer side effects.","summary":"Charlotte Coles was chief investigator of IMPORT LOW, the UK trial showing partial-breast radiotherapy after breast conservation matches whole-breast radiotherapy for local control with less breast hardening, and co-led IMPORT HIGH and the PRIMETIME study of radiotherapy omission. She chaired the Lancet Breast Cancer Commission and is a leader in ESTRO. Her work drives the shift to shorter, more targeted breast radiotherapy.","asOf":"2026-09-10","wikipedia":"https://en.wikipedia.org/wiki/Charlotte_Coles","links":[{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Coles%20CE%5BAuthor%5D%20breast%20radiotherapy%20IMPORT"}],"tags":["radiotherapy","breast","de-escalation"],"related":[],"cancers":["breast-hr-positive"],"sections":[],"technologies":["imrt-igrt"],"targets":[],"drugs":[],"companies":[],"institutions":["cruk-cambridge-centre","estro"],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"role":"Professor of Breast Cancer Clinical Oncology, University of Cambridge; Consultant, Addenbrooke's Hospital","institutionId":"cruk-cambridge-centre","specialisms":["Breast radiotherapy","Partial breast irradiation","Hypofractionation","Radiotherapy de-escalation"],"profiles":[{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Coles%20CE%5BAuthor%5D%20breast%20radiotherapy%20IMPORT"}],"papers":[{"title":"Partial-breast radiotherapy after breast conservation surgery for patients with early breast cancer (UK IMPORT LOW trial): 5-year results from a multicentre, randomised, controlled, phase 3, non-inferiority trial","journal":"Lancet","year":2017,"doi":"10.1016/S0140-6736(17)31145-5"},{"title":"The Lancet Breast Cancer Commission","journal":"Lancet","year":2024,"doi":"10.1016/S0140-6736(24)00747-5"}],"orcid":"0000-0003-4473-8552"},"route":"/people/charlotte-coles/","neighbours":{"cancer":[{"id":"breast-hr-positive","kind":"cancer","name":"HR-positive / HER2-negative breast cancer","route":"/cancers/breast-hr-positive/"}],"technology":[{"id":"imrt-igrt","kind":"technology","name":"IMRT / IGRT (modern external beam)","route":"/technologies/imrt-igrt/"}],"institution":[{"id":"cruk-cambridge-centre","kind":"institution","name":"Cancer Research UK Cambridge Centre / CRUK Cambridge Institute","route":"/institutions/cruk-cambridge-centre/"},{"id":"estro","kind":"institution","name":"European Society for Radiotherapy and Oncology","route":"/institutions/estro/"}]}}