{"entity":{"id":"charles-sawyers","kind":"person","name":"Charles L. Sawyers","aka":[],"tldr":"Co-developed imatinib's successor dasatinib and the prostate drug enzalutamide, and explained how cancers resist targeted drugs.","summary":"Physician-scientist who characterised BCR-ABL resistance mutations, co-developed dasatinib, and with Michael Jung co-invented enzalutamide and apalutamide. His laboratory studies androgen receptor signalling and lineage plasticity in castration-resistant prostate cancer. Lasker Award 2009, Breakthrough Prize 2013.","asOf":"2026-09-08","wikipedia":"https://en.wikipedia.org/wiki/Charles_Sawyers","links":[{"label":"MSK lab","url":"https://www.mskcc.org/research-areas/labs/charles-sawyers"},{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Sawyers%20CL%5BAuthor%5D"}],"tags":[],"related":[],"cancers":["prostate"],"sections":[],"technologies":[],"targets":["androgen-receptor","bcr-abl"],"drugs":["enzalutamide","apalutamide","dasatinib"],"companies":[],"institutions":["mskcc"],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"role":"Chair, Human Oncology and Pathogenesis Program; HHMI Investigator","institutionId":"mskcc","specialisms":["Prostate cancer","Kinase inhibitor resistance","Androgen receptor biology","Lineage plasticity"],"profiles":[{"label":"MSK lab","url":"https://www.mskcc.org/research-areas/labs/charles-sawyers"},{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Sawyers%20CL%5BAuthor%5D"}],"papers":[{"title":"Development of a second-generation antiandrogen for treatment of advanced prostate cancer","journal":"Science","year":2009,"url":"https://doi.org/10.1126/science.1168175","doi":"10.1126/science.1168175"},{"title":"Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification","journal":"Science","year":2001,"url":"https://doi.org/10.1126/science.1062538","doi":"10.1126/science.1062538"}],"orcid":"0000-0003-4955-6475"},"route":"/people/charles-sawyers/","neighbours":{"cancer":[{"id":"prostate","kind":"cancer","name":"Prostate cancer","route":"/cancers/prostate/"}],"target":[{"id":"androgen-receptor","kind":"target","name":"Androgen receptor","route":"/targets/androgen-receptor/"},{"id":"bcr-abl","kind":"target","name":"BCR::ABL1 (Philadelphia chromosome)","route":"/targets/bcr-abl/"}],"drug":[{"id":"apalutamide","kind":"drug","name":"Apalutamide","route":"/drugs/apalutamide/"},{"id":"dasatinib","kind":"drug","name":"Dasatinib","route":"/drugs/dasatinib/"},{"id":"enzalutamide","kind":"drug","name":"Enzalutamide","route":"/drugs/enzalutamide/"}],"institution":[{"id":"hhmi","kind":"institution","name":"Howard Hughes Medical Institute","route":"/institutions/hhmi/"},{"id":"mskcc","kind":"institution","name":"Memorial Sloan Kettering Cancer Center","route":"/institutions/mskcc/"},{"id":"pcf","kind":"institution","name":"Prostate Cancer Foundation","route":"/institutions/pcf/"},{"id":"stand-up-to-cancer","kind":"institution","name":"Stand Up To Cancer","route":"/institutions/stand-up-to-cancer/"}],"paper":[{"id":"paper-taylor-integrative-genomic-profiling-cancer-cell-2010","kind":"paper","name":"Integrative genomic profiling of human prostate cancer","route":"/key-papers/paper-taylor-integrative-genomic-profiling-cancer-cell-2010/"},{"id":"paper-chen-androgen-receptor-overexpression-antiandrogen-resistance-nat-med-2004","kind":"paper","name":"Molecular determinants of resistance to antiandrogen therapy","route":"/key-papers/paper-chen-androgen-receptor-overexpression-antiandrogen-resistance-nat-med-2004/"},{"id":"paper-mu-sox2-lineage-plasticity-science-2017","kind":"paper","name":"SOX2 promotes lineage plasticity and antiandrogen resistance in TP53- and RB1-deficient prostate cancer","route":"/key-papers/paper-mu-sox2-lineage-plasticity-science-2017/"},{"id":"paper-robinson-integrative-clinical-genomics-advanced-prostate-cell-2015","kind":"paper","name":"SU2C-PCF: integrative clinical genomics of advanced prostate cancer","route":"/key-papers/paper-robinson-integrative-clinical-genomics-advanced-prostate-cell-2015/"}],"person":[{"id":"brian-druker","kind":"person","name":"Brian Druker","route":"/people/brian-druker/"},{"id":"michael-milken","kind":"person","name":"Michael Milken","route":"/people/michael-milken/"}]}}