{"entity":{"id":"chai-discovery","kind":"company","name":"Chai Discovery","aka":[],"tldr":"Makes Chai-1 and Chai-2, open-weight structure models used for antibody and binder design.","summary":"Chai Discovery, based in San Francisco, makes Chai-1 and Chai-2, open-weight structure prediction models used for antibody and binder design. Chai-1, released in 2024, matched AlphaFold 3 on many benchmarks with open weights for non-commercial use, and Chai-2, released in 2025, reported zero-shot de novo antibody hit rates far above earlier methods. OnCo links it to the Chai-1 and Chai-2 technology record. Whether high computational hit rates translate into antibodies that behave in patients is the open question. Chai-1 and Chai-2 have their own technology page.","asOf":"2026-09-08","links":[{"label":"Official website","url":"https://www.chaidiscovery.com"}],"tags":["ai","protein-design"],"related":[],"cancers":[],"sections":["drug-discovery","ai-computation"],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"hq":"San Francisco, CA","country":"US","companyType":"ai-software","website":"https://www.chaidiscovery.com","investors":[],"funding":[]},"route":"/companies/chai-discovery/","neighbours":{"section":[{"id":"ai-computation","kind":"section","name":"AI & Computation","route":"/fronts/ai-computation/"},{"id":"drug-discovery","kind":"section","name":"Drug Discovery Platforms","route":"/fronts/drug-discovery/"}],"technology":[{"id":"chai-1","kind":"technology","name":"Chai-1 / Chai-2","route":"/technologies/chai-1/"}],"roadmap":[{"id":"drug-discovery-roadmap","kind":"roadmap","name":"Drug discovery roadmap: screening in mice → maps of dependency → designing in silico","route":"/roadmaps/drug-discovery-roadmap/"}]}}