{"entity":{"id":"cell-therapy-cold-chain","kind":"technology","name":"Cryopreservation and cell-therapy cold chain","aka":[],"tldr":"Freezing cells at minus 150 degrees and shipping them in liquid-nitrogen 'dry shippers' with tracking, so a living drug arrives alive and matched to the right patient.","summary":"Cryoport, BioLife Solutions (CryoStor media, evo shippers), Cryoport's CRYOPDP, World Courier (Cencora), and Marken (UPS) provide validated cryogenic logistics with temperature and location telemetry; chain-of-identity and chain-of-custody software (Vineti, TrakCel, Ori, Kite's Konnect) links apheresis, manufacturing, and infusion. Failures here are rare but catastrophic for an individualised product.","status":"established","asOf":"2026-09-08","links":[{"label":"FDA guidance: considerations for the development of CAR T cell products","url":"https://www.fda.gov/regulatory-information/search-fda-guidance-documents/considerations-development-chimeric-antigen-receptor-car-t-cell-products"}],"tags":["supporting"],"related":[],"cancers":[],"sections":["cell-therapy"],"technologies":["car-t","apheresis-starting-material","cell-therapy-orchestration-software"],"targets":[],"drugs":[],"companies":["cryoport","biolife-solutions"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"principle":"Controlled-rate freezing in DMSO-based media, storage below -150°C in vapour-phase nitrogen, and GPS/temperature-logged dry shippers with digital identity verification at each hand-off.","strengths":["Enables centralised manufacturing across continents","Full audit trail"],"limitations":["Cost per shipment","Cryo-injury reduces viability","Dependence on a few specialist couriers"]},"route":"/technologies/cell-therapy-cold-chain/","neighbours":{"section":[{"id":"cell-therapy","kind":"section","name":"Cell Therapy","route":"/fronts/cell-therapy/"}],"technology":[{"id":"allogeneic-cell-therapy","kind":"technology","name":"Allogeneic (off-the-shelf) cell therapy","route":"/technologies/allogeneic-cell-therapy/"},{"id":"allogeneic-cell-banks","kind":"technology","name":"Allogeneic cell banks: one donor, hundreds of doses","route":"/technologies/allogeneic-cell-banks/"},{"id":"allogeneic-cell-banking","kind":"technology","name":"Allogeneic donor and iPSC master cell banks","route":"/technologies/allogeneic-cell-banking/"},{"id":"apheresis-starting-material","kind":"technology","name":"Apheresis and starting-material collection","route":"/technologies/apheresis-starting-material/"},{"id":"car-t-manufacturing-process","kind":"technology","name":"Autologous CAR-T manufacturing, batch by batch","route":"/technologies/car-t-manufacturing-process/"},{"id":"autologous-stem-cell-transplant","kind":"technology","name":"Autologous stem cell transplant (high-dose therapy)","route":"/technologies/autologous-stem-cell-transplant/"},{"id":"car-t","kind":"technology","name":"CAR-T cell therapy","route":"/technologies/car-t/"},{"id":"cell-therapy-orchestration-software","kind":"technology","name":"Cell-therapy orchestration and chain-of-identity software","route":"/technologies/cell-therapy-orchestration-software/"},{"id":"mrna-lnp-manufacturing","kind":"technology","name":"mRNA and lipid nanoparticle manufacturing","route":"/technologies/mrna-lnp-manufacturing/"},{"id":"nk-cell-therapy","kind":"technology","name":"NK cell therapy and CAR-NK","route":"/technologies/nk-cell-therapy/"},{"id":"tcr-t","kind":"technology","name":"TCR-T cell therapy","route":"/technologies/tcr-t/"},{"id":"til-therapy","kind":"technology","name":"TIL therapy","route":"/technologies/til-therapy/"}],"company":[{"id":"biolife-solutions","kind":"company","name":"BioLife Solutions","route":"/companies/biolife-solutions/"},{"id":"cryoport","kind":"company","name":"Cryoport","route":"/companies/cryoport/"}]}}