{"entity":{"id":"cda","kind":"target","name":"CDA","aka":["cytidine deaminase","Cytidine deaminase"],"tldr":"CDA (Cytidine deaminase) is an enzyme. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Leukaemia, Myeloproliferative neoplasms and Myelodysplastic syndromes / neoplasms.","summary":"This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.\n\nOpen Targets scores its association with cancer at 0.54 (direct and indirect evidence; datatypes literature 0.92, genetic association 0.00, clinical 0.84).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:1712","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1712"},{"label":"UniProt P32320","url":"https://www.uniprot.org/uniprotkb/P32320/entry"},{"label":"NCBI Gene 978","url":"https://www.ncbi.nlm.nih.gov/gene/978"},{"label":"Ensembl ENSG00000158825","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000158825"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["leukaemia","myeloproliferative-neoplasms","mds"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.84. Evidence tier \"approved-drug\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"CDA","role":["drug-target"],"evidenceTier":"approved-drug","sources":[{"label":"HGNC HGNC:1712","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1712","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P32320","url":"https://www.uniprot.org/uniprotkb/P32320/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000158825","url":"https://platform.opentargets.org/target/ENSG00000158825/associations","note":"association with cancer (MONDO_0004992) 0.54; per-cancer scores at or above 0.5: myelodysplastic syndrome 0.51, myeloproliferative neoplasm 0.53, leukaemia 0.53 (GraphQL API, CC0)"}],"distribution":"few-types","specificityNote":"Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the role drug-target; HPA finds the RNA tissue enhanced, which says where the protein sits but not whether the tumour differs from normal tissue. HPA CDA: RNA tissue enhanced (bone marrow 183 nTPM, esophagus 108 nTPM, liver 81 nTPM); blood lineage lineage enriched (granulocytes 1,240 nTPM); no normal tissue stained high. Distribution: 2 cancer families in the corpus carry a prevalence row, label threshold or catalogue link for it (Leukaemia, Myeloid neoplasms); Open Targets associates it with 1 specific cancer type at or above 0.5 (myelodysplastic syndrome). (No rule of scripts/fetch-target-specificity.ts fired.)","specificitySources":[{"label":"Human Protein Atlas CDA tissue","url":"https://www.proteinatlas.org/ENSG00000158825-CDA/tissue","note":"RNA tissue and blood lineage specificity, normal tissue antibody staining (version 25.1, CC BY-SA 3.0)"},{"label":"Open Targets ENSG00000158825 associations","url":"https://platform.opentargets.org/target/ENSG00000158825/associations","note":"cancer associations at or above 0.5 (CC0)"}],"hgnc":"HGNC:1712","ensembl":"ENSG00000158825","uniprot":"P32320","entrez":"978","firstDescribed":1993,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: Kuhn et al, Biochem. Biophys. Res. Commun, 1993, \"Cloning of a functional cDNA for human cytidine deaminase (CDD) and its use as a marker of monocyte/macrophage differentiation\".","firstDescribedSource":"https://pubmed.ncbi.nlm.nih.gov/8422236/","biology":"This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis. Locus 1p36.12 (HGNC).","whereFound":["Leukaemia: Open Targets association 0.53 with leukaemia (MONDO_0005059)","Myeloproliferative neoplasms: Open Targets association 0.53 with myeloproliferative neoplasm (MONDO_0020076)","Myelodysplastic syndromes / neoplasms: Open Targets association 0.51 with myelodysplastic syndrome (MONDO_0018881)"],"targetClass":"enzyme","prevalence":[]},"route":"/targets/cda/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"leukaemia","kind":"cancer","name":"Leukaemia (all types)","route":"/cancers/leukaemia/"},{"id":"mds","kind":"cancer","name":"Myelodysplastic syndromes / neoplasms (MDS)","route":"/cancers/mds/"},{"id":"myeloproliferative-neoplasms","kind":"cancer","name":"Myeloproliferative neoplasms (PV, ET, myelofibrosis)","route":"/cancers/myeloproliferative-neoplasms/"}]}}