{"entity":{"id":"case-ccc","kind":"institution","name":"Case Comprehensive Cancer Center","aka":["Case CCC"],"tldr":"The NCI comprehensive consortium uniting Case Western Reserve University, University Hospitals Seidman Cancer Center and Cleveland Clinic.","summary":"NCI-designated since 1987 and comprehensive since 1998, Case Comprehensive Cancer Center is a consortium of Case Western Reserve University, University Hospitals Seidman Cancer Center and Cleveland Clinic's Taussig Cancer Institute. Sanford Markowitz's colon cancer genetics (TGF-beta receptor II inactivation, 15-PGDH) led to stool methylated-DNA screening markers and chemoprevention concepts; UH Seidman opened a compact Mevion proton centre in 2016. The consortium offers patients across north-east Ohio a shared portfolio of NCI cooperative group and investigator-initiated trials, and its members include Cleveland Clinic's Lerner Research Institute.","asOf":"2026-09-09","wikipedia":"https://en.wikipedia.org/wiki/Case_Comprehensive_Cancer_Center","links":[{"label":"Case Comprehensive Cancer Center","url":"https://case.edu/cancer/"},{"label":"UH Seidman Cancer Center","url":"https://www.uhhospitals.org/services/cancer-services"}],"tags":[],"related":[],"cancers":["colorectal"],"sections":["early-detection"],"technologies":["colorectal-screening","proton-therapy","methylation-profiling"],"targets":[],"drugs":[],"companies":["mevion"],"institutions":["cleveland-clinic"],"pathways":[],"terms":[],"trials":[],"people":["daniel-spratt"],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"city":"Cleveland, OH","country":"US","lat":41.505,"lng":-81.606,"institutionType":"consortium","website":"https://case.edu/cancer/","nci":"comprehensive","university":"Case Western Reserve University","programs":["Colorectal cancer genetics and screening","Proton therapy (UH Seidman)","Consortium trial network"]},"route":"/institutions/case-ccc/","neighbours":{"cancer":[{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"}],"section":[{"id":"early-detection","kind":"section","name":"Early Detection & Screening","route":"/fronts/early-detection/"}],"technology":[{"id":"colorectal-screening","kind":"technology","name":"Colorectal cancer screening (colonoscopy, FIT, stool DNA, blood)","route":"/technologies/colorectal-screening/"},{"id":"methylation-profiling","kind":"technology","name":"DNA methylation profiling","route":"/technologies/methylation-profiling/"},{"id":"proton-therapy","kind":"technology","name":"Proton therapy","route":"/technologies/proton-therapy/"}],"company":[{"id":"mevion","kind":"company","name":"Mevion Medical Systems","route":"/companies/mevion/"}],"institution":[{"id":"cleveland-clinic","kind":"institution","name":"Cleveland Clinic Taussig Cancer Institute","route":"/institutions/cleveland-clinic/"},{"id":"nci","kind":"institution","name":"National Cancer Institute (NIH)","route":"/institutions/nci/"}],"person":[{"id":"daniel-spratt","kind":"person","name":"Daniel E. Spratt","route":"/people/daniel-spratt/"}]}}