{"entity":{"id":"carien-creutzberg","kind":"person","name":"Carien L. Creutzberg","aka":[],"tldr":"Led the PORTEC trials that defined who needs radiotherapy for endometrial cancer and brought molecular classification into treatment decisions.","summary":"Carien Creutzberg led PORTEC-1, -2 and -3, the Dutch trials that established vaginal brachytherapy over external beam radiotherapy for intermediate-risk endometrial cancer and tested chemoradiotherapy for high-risk disease, and pioneered the integration of the TCGA molecular classification (POLE, MMRd, p53abn, NSMP) into the PORTEC-4a trial and ESGO-ESTRO-ESP guidelines. She co-leads the RAINBO platform of molecularly directed adjuvant trials.","asOf":"2026-09-10","links":[{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Creutzberg%20CL%5BAuthor%5D%20PORTEC"}],"tags":["endometrial","radiotherapy","molecular-classification"],"related":[],"cancers":["endometrial"],"sections":[],"technologies":["brachytherapy","imrt-igrt"],"targets":[],"drugs":[],"companies":[],"institutions":["lumc-leiden"],"pathways":[],"terms":[],"trials":["portec-3"],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"role":"Professor of Radiation Oncology, Leiden University Medical Center","institutionId":"lumc-leiden","specialisms":["Endometrial cancer","Radiotherapy","Molecular classification","Cooperative-group trials"],"profiles":[{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Creutzberg%20CL%5BAuthor%5D%20PORTEC"}],"papers":[{"title":"Adjuvant chemoradiotherapy versus radiotherapy alone for women with high-risk endometrial cancer (PORTEC-3): final results of an international, open-label, multicentre, randomised, phase 3 trial","journal":"Lancet Oncology","year":2018,"doi":"10.1016/S1470-2045(18)30079-2"},{"title":"Vaginal brachytherapy versus pelvic external beam radiotherapy for patients with endometrial cancer of high-intermediate risk (PORTEC-2)","journal":"Lancet","year":2010,"doi":"10.1016/S0140-6736(09)62163-2"}],"orcid":"0000-0002-7008-4321"},"route":"/people/carien-creutzberg/","neighbours":{"cancer":[{"id":"endometrial","kind":"cancer","name":"Endometrial cancer","route":"/cancers/endometrial/"}],"technology":[{"id":"brachytherapy","kind":"technology","name":"Brachytherapy","route":"/technologies/brachytherapy/"},{"id":"imrt-igrt","kind":"technology","name":"IMRT / IGRT (modern external beam)","route":"/technologies/imrt-igrt/"}],"institution":[{"id":"lumc-leiden","kind":"institution","name":"Leiden University Medical Center","route":"/institutions/lumc-leiden/"}],"trial":[{"id":"portec-3","kind":"trial","name":"PORTEC-3","route":"/trials/portec-3/"}]}}