{"entity":{"id":"caetano-reis-e-sousa","kind":"person","name":"Caetano Reis e Sousa","aka":[],"tldr":"Immunologist who works out how dendritic cells detect dying tumour cells and start an anti-cancer response.","summary":"Caetano Reis e Sousa is Principal Group Leader of the Immunobiology Laboratory at The Francis Crick Institute in London. His specialisms are innate immunity, dendritic cells and cross-presentation. He studies the receptors dendritic cells use to sense dead cells and viruses, including DNGR-1 and other C-type lectins, and how those signals let dendritic cells prime T cells. His Current Opinion in Immunology paper reviewed how myeloid C-type lectin receptors sense cell death. This work explains how the immune system detects dying tumour cells and underpins cancer vaccination and immunotherapy. His publications are listed on PubMed.","asOf":"2026-09-08","links":[{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Reis%20e%20Sousa%20C%5BAuthor%5D%20dendritic"}],"tags":[],"related":[],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":["francis-crick"],"pathways":["pd1-checkpoint"],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"role":"Principal Group Leader, Immunobiology Laboratory, Francis Crick Institute","institutionId":"francis-crick","specialisms":["Innate immunity","Dendritic cells","Cross-presentation"],"profiles":[{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Reis%20e%20Sousa%20C%5BAuthor%5D%20dendritic"}],"papers":[{"title":"Sensing of cell death by myeloid C-type lectin receptors","journal":"Current Opinion in Immunology","year":2012}]},"route":"/people/caetano-reis-e-sousa/","neighbours":{"institution":[{"id":"francis-crick","kind":"institution","name":"The Francis Crick Institute","route":"/institutions/francis-crick/"}],"pathway":[{"id":"pd1-checkpoint","kind":"pathway","name":"PD-1 / PD-L1 immune checkpoint & T-cell activation","route":"/pathways/pd1-checkpoint/"}],"idea":[{"id":"idea-bio2-trem2-myeloid-reprogramming","kind":"idea","name":"Reprogramme suppressive macrophages instead of trying to delete them","route":"/ideas/idea-bio2-trem2-myeloid-reprogramming/"}]}}