{"entity":{"id":"ca-125","kind":"term","name":"CA-125","aka":[],"tldr":"A blood protein that rises in most ovarian cancers; useful for tracking treatment, useless for screening on its own.","summary":"MUC16 glycoprotein elevated in ~80% of advanced high-grade serous ovarian cancers but also in endometriosis, pregnancy, and other cancers. Used to monitor response (GCIG criteria) and relapse; UKCTOCS showed a CA-125 algorithm plus ultrasound detects cancer earlier without reducing deaths. HE4 and the ROMA index refine triage of pelvic masses.","asOf":"2026-09-07","wikipedia":"https://en.wikipedia.org/wiki/CA-125","links":[{"label":"Wikipedia","url":"https://en.wikipedia.org/wiki/CA-125"}],"tags":[],"related":[],"cancers":["ovarian"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":["ukctocs"],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"category":"Biomarkers"},"route":"/terms/ca-125/","neighbours":{"cancer":[{"id":"ovarian","kind":"cancer","name":"Ovarian cancer","route":"/cancers/ovarian/"}],"trial":[{"id":"ukctocs","kind":"trial","name":"UKCTOCS","route":"/trials/ukctocs/"}],"target":[{"id":"muc16","kind":"target","name":"MUC16 (CA-125)","route":"/targets/muc16/"}],"collection":[{"id":"ovarian-cancer-research-alliance","kind":"collection","name":"Ovarian Cancer Research Alliance (OCRA)","route":"/collections/ovarian-cancer-research-alliance/"}],"technology":[{"id":"serum-tumour-markers","kind":"technology","name":"Serum tumour markers: proper use and misuse","route":"/technologies/serum-tumour-markers/"}]}}