{"entity":{"id":"bruce-stillman","kind":"person","name":"Bruce W. Stillman","aka":[],"tldr":"Bruce Stillman discovered how DNA replication starts, the process cancer cells push into overdrive.","summary":"Bruce W. Stillman is President and Chief Executive Officer of Cold Spring Harbor Laboratory, which he has led since 1994. He is a molecular biologist known for discovering how DNA replication starts, identifying the origin recognition complex and the mechanisms of chromatin assembly during replication. His selected paper describes ATP-dependent recognition of eukaryotic origins of DNA replication by a multiprotein complex. His research on DNA replication, chromatin and genome stability bears on the process that cancer cells push into overdrive.","asOf":"2026-09-08","links":[{"label":"CSHL leadership","url":"https://www.cshl.edu/about-us/leadership/"},{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Stillman%20B%5BAuthor%5D"}],"tags":[],"related":[],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":["cold-spring-harbor"],"pathways":["p53-cell-cycle"],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"role":"President and Chief Executive Officer","institutionId":"cold-spring-harbor","specialisms":["DNA replication","Chromatin","Genome stability"],"profiles":[{"label":"CSHL leadership","url":"https://www.cshl.edu/about-us/leadership/"},{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Stillman%20B%5BAuthor%5D"}],"papers":[{"title":"ATP-dependent recognition of eukaryotic origins of DNA replication by a multiprotein complex","journal":"Nature","year":1992,"url":"https://doi.org/10.1038/357128a0","doi":"10.1038/357128a0"}],"orcid":"0000-0002-9453-4091"},"route":"/people/bruce-stillman/","neighbours":{"institution":[{"id":"cold-spring-harbor","kind":"institution","name":"Cold Spring Harbor Laboratory","route":"/institutions/cold-spring-harbor/"}],"pathway":[{"id":"p53-cell-cycle","kind":"pathway","name":"p53 / RB / cell-cycle checkpoint","route":"/pathways/p53-cell-cycle/"}]}}