{"entity":{"id":"bostongene","kind":"company","name":"BostonGene","aka":[],"tldr":"BostonGene, of Waltham, Massachusetts, sells the Tumor Portrait, a single report combining genomic, transcriptomic and immune microenvironment analysis that sorts tumours into immune-enriched, fibrotic or depleted subtypes to guide immunotherapy decisions. Whether those subtypes predict immunotherapy response well enough to change practice is unproven.","summary":"BostonGene, based in Waltham, Massachusetts, integrates genomic, transcriptomic and immune microenvironment analysis into a single report it calls the Tumor Portrait. The test classifies the tumour microenvironment into subtypes, including immune-enriched, fibrotic and depleted, to guide immunotherapy decisions. OnCo links it to RNA sequencing and expression profiling, to comprehensive genomic profiling, to spatial-omics-guided treatment selection, and to the idea of turning the map of immune cells inside a tumour into a standardised test. Whether microenvironment subtypes predict immunotherapy response well enough to change practice is the open question, and data silos are the bottleneck the company confronts. The technology pages carry the wider evidence.","asOf":"2026-09-04","links":[{"label":"Official website","url":"https://bostongene.com"}],"tags":[],"related":[],"cancers":[],"sections":["diagnostics","ai-computation"],"technologies":["rna-seq","cgp","wes-wgs"],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"hq":"Waltham, MA","country":"US","companyType":"ai-software","website":"https://bostongene.com","investors":[],"funding":[]},"route":"/companies/bostongene/","neighbours":{"section":[{"id":"ai-computation","kind":"section","name":"AI & Computation","route":"/fronts/ai-computation/"},{"id":"diagnostics","kind":"section","name":"Diagnostics & Biomarkers","route":"/fronts/diagnostics/"}],"technology":[{"id":"cgp","kind":"technology","name":"Comprehensive genomic profiling","route":"/technologies/cgp/"},{"id":"rna-seq","kind":"technology","name":"RNA sequencing & expression profiling","route":"/technologies/rna-seq/"},{"id":"spatial-omics-guided-therapy","kind":"technology","name":"Spatial-omics-guided treatment selection","route":"/technologies/spatial-omics-guided-therapy/"},{"id":"wes-wgs","kind":"technology","name":"Whole-exome & whole-genome sequencing","route":"/technologies/wes-wgs/"}],"bottleneck":[{"id":"b-data-silos","kind":"bottleneck","name":"Data silos","route":"/bottlenecks/b-data-silos/"}],"idea":[{"id":"idea-bio2-spatial-signature-cdx","kind":"idea","name":"Turn the map of immune cells inside a tumour into a standardised test","route":"/ideas/idea-bio2-spatial-signature-cdx/"}]}}