{"entity":{"id":"bio-106","kind":"drug","name":"BIO-106","aka":[],"tldr":"BIO-106 is an experimental antibody-drug conjugate from BiOneCure Therapeutics in phase 2 trials, aimed at TROP2.","summary":"BIO-106 is an antibody-drug conjugate developed by BiOneCure Therapeutics. Its target is TROP2 (the sponsor names Trop-2). The sponsor states: BIO-106 is a novel antibody-drug conjugate targeting the human trophoblast cell surface antigen 2 (Trop-2). ClinicalTrials.gov describes the intervention as: BIO-106 is a novel antibody-drug conjugate (ADC) that targets the human trophoblast cell surface antigen 2 (Trop-2). It is the investigational product in 1 recruiting or active industry-led phase 2 and phase 3 interventional cancer trial. The largest, NCT05320588, plans to enrol 332 participants with primary completion was scheduled for 2024-04 on the registry. Status reflects the highest phase registered on ClinicalTrials.gov; no efficacy results are recorded here.","status":"phase-2","asOf":"2026-09-11","links":[{"label":"ClinicalTrials.gov: trials of BIO-106","url":"https://clinicaltrials.gov/search?intr=BIO-106"}],"tags":["pipeline","ctgov-ingest"],"related":[],"cancers":[],"sections":[],"technologies":["adc"],"targets":["trop2"],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":["nct05320588"],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"provenance":{"editedBy":"OnCo ingestion (ClinicalTrials.gov v2 + sponsor pipeline pages)","editedOn":"2026-09-11"},"modality":"ADC","mechanism":"BIO-106 is a novel antibody-drug conjugate targeting the human trophoblast cell surface antigen 2 (Trop-2).","approvals":[],"mechanismSteps":[],"toxicity":[],"access":[],"regulatoryEvents":[]},"route":"/drugs/bio-106/","neighbours":{"technology":[{"id":"adc","kind":"technology","name":"Antibody-drug conjugate (ADC)","route":"/technologies/adc/"}],"target":[{"id":"trop2","kind":"target","name":"TROP2","route":"/targets/trop2/"}],"trial":[{"id":"nct05320588","kind":"trial","name":"A Study in Patients With Advanced Cancers","route":"/trials/nct05320588/"}]}}