{"entity":{"id":"biliary-anatomy-subtypes","kind":"term","name":"Intrahepatic, perihilar, distal and gallbladder cancer","aka":[],"tldr":"Bile duct cancers are named by where they start: inside the liver, at the hilum where the ducts join, in the lower duct near the pancreas, or in the gallbladder. Each behaves and mutates differently.","summary":"Intrahepatic cholangiocarcinoma (iCCA) carries FGFR2 fusions (~10-15%) and IDH1 mutations (~15%) and is rising in incidence; perihilar (Klatskin) and distal tumours are more often HER2-amplified or KRAS-mutant; gallbladder cancer has the highest HER2 prevalence (~15-20%) and is common in Chile, India and among Indigenous Americans. Molecular profiling is guideline-recommended for all advanced biliary cancers.","asOf":"2026-09-07","wikipedia":"https://en.wikipedia.org/wiki/Cholangiocarcinoma","links":[{"label":"Wikipedia","url":"https://en.wikipedia.org/wiki/Cholangiocarcinoma"}],"tags":[],"related":[],"cancers":["cholangiocarcinoma"],"sections":[],"technologies":[],"targets":["fgfr2","idh","her2"],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"category":"Clinical"},"route":"/terms/biliary-anatomy-subtypes/","neighbours":{"cancer":[{"id":"cholangiocarcinoma","kind":"cancer","name":"Biliary tract cancer (cholangiocarcinoma)","route":"/cancers/cholangiocarcinoma/"},{"id":"cystic-duct-carcinoma","kind":"cancer","name":"Cystic duct carcinoma","route":"/cancers/cystic-duct-carcinoma/"},{"id":"gallbladder","kind":"cancer","name":"Gallbladder cancer","route":"/cancers/gallbladder/"}],"target":[{"id":"fgfr2","kind":"target","name":"FGFR2","route":"/targets/fgfr2/"},{"id":"her2","kind":"target","name":"HER2","route":"/targets/her2/"},{"id":"idh","kind":"target","name":"IDH1 / IDH2","route":"/targets/idh/"}],"term":[{"id":"gallbladder-cancer-in-biliary-trials","kind":"term","name":"Gallbladder cancer in biliary tract cancer trials (eligibility and subgroups)","route":"/terms/gallbladder-cancer-in-biliary-trials/"}]}}