{"entity":{"id":"bert-vogelstein","kind":"person","name":"Bert Vogelstein","aka":[],"tldr":"Bert Vogelstein is the most-cited scientist in cancer genetics: he mapped how colorectal cancer develops and founded the field of cancer genome sequencing and blood-based detection.","summary":"Bert Vogelstein is Clayton Professor of Oncology, Co-Director of the Ludwig Center and an HHMI Investigator at Johns Hopkins Hospital and the Sidney Kimmel Comprehensive Cancer Center. He is the most-cited scientist in cancer genetics, having mapped with Kenneth Kinzler how colorectal cancer develops through the adenoma-carcinoma sequence, discovered the tumour-suppressor role of p53 and sequenced the first cancer genomes. His selected papers survey cancer genome landscapes and describe detection and localisation of surgically resectable cancers with a multi-analyte blood test. That test, CancerSEEK, is the basis of multi-cancer early detection, and his laboratory continues to work on liquid biopsy and blood-based screening.","asOf":"2026-09-08","wikipedia":"https://en.wikipedia.org/wiki/Bert_Vogelstein","links":[{"label":"Ludwig Center","url":"https://www.hopkinsmedicine.org/kimmel-cancer-center/research/ludwig-center"},{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Vogelstein%20B%5BAuthor%5D"}],"tags":[],"related":[],"cancers":["colorectal","pancreatic"],"sections":[],"technologies":["mced","liquid-biopsy","wes-wgs"],"targets":["tp53","kras"],"drugs":[],"companies":[],"institutions":["johns-hopkins"],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"role":"Clayton Professor of Oncology; Co-Director, Ludwig Center; HHMI Investigator","institutionId":"johns-hopkins","specialisms":["Cancer genetics","Colorectal tumorigenesis","Liquid biopsy","Early detection"],"profiles":[{"label":"Ludwig Center","url":"https://www.hopkinsmedicine.org/kimmel-cancer-center/research/ludwig-center"},{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Vogelstein%20B%5BAuthor%5D"}],"papers":[{"title":"Cancer genome landscapes","journal":"Science","year":2013,"url":"https://doi.org/10.1126/science.1235122","doi":"10.1126/science.1235122"},{"title":"Detection and localization of surgically resectable cancers with a multi-analyte blood test","journal":"Science","year":2018,"url":"https://doi.org/10.1126/science.aar3247","doi":"10.1126/science.aar3247"},{"title":"DETECT-A: a blood test plus PET-CT found treatable cancers in 10,000 women with no symptoms","journal":"Science","year":2020,"url":"https://doi.org/10.1126/science.abb9601","doi":"10.1126/science.abb9601"},{"title":"DYNAMIC: a blood test safely halved chemotherapy use after surgery for stage II colon cancer","journal":"New England Journal of Medicine","year":2022,"url":"https://doi.org/10.1056/NEJMoa2200075","doi":"10.1056/NEJMoa2200075"},{"title":"El-Deiry 1993: WAF1, the gene through which p53 stops cell division","journal":"Cell","year":1993,"url":"https://doi.org/10.1016/0092-8674(93)90500-P","doi":"10.1016/0092-8674(93)90500-P"},{"title":"Hollstein 1991: p53 mutations in human cancers","journal":"Science","year":1991,"url":"https://doi.org/10.1126/science.1905840","doi":"10.1126/science.1905840"},{"title":"Vogelstein, Lane and Levine 2000: surfing the p53 network","journal":"Nature","year":2000,"url":"https://doi.org/10.1038/35042675","doi":"10.1038/35042675"}]},"route":"/people/bert-vogelstein/","neighbours":{"cancer":[{"id":"brca-palb2-pdac","kind":"cancer","name":"BRCA or PALB2-mutant pancreatic ductal adenocarcinoma","route":"/cancers/brca-palb2-pdac/"},{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"},{"id":"ipmn-cystic-precursors","kind":"cancer","name":"Intraductal papillary mucinous neoplasm and other pancreatic cystic precursors","route":"/cancers/ipmn-cystic-precursors/"},{"id":"msi-high-pdac","kind":"cancer","name":"Mismatch repair deficient (MSI-high) pancreatic ductal adenocarcinoma","route":"/cancers/msi-high-pdac/"},{"id":"pancreatic","kind":"cancer","name":"Pancreatic ductal adenocarcinoma","route":"/cancers/pancreatic/"}],"technology":[{"id":"liquid-biopsy","kind":"technology","name":"Liquid biopsy (ctDNA)","route":"/technologies/liquid-biopsy/"},{"id":"mced","kind":"technology","name":"Multi-cancer early detection (MCED)","route":"/technologies/mced/"},{"id":"wes-wgs","kind":"technology","name":"Whole-exome & whole-genome sequencing","route":"/technologies/wes-wgs/"}],"target":[{"id":"kras","kind":"target","name":"KRAS","route":"/targets/kras/"},{"id":"tp53","kind":"target","name":"TP53","route":"/targets/tp53/"}],"institution":[{"id":"hhmi","kind":"institution","name":"Howard Hughes Medical Institute","route":"/institutions/hhmi/"},{"id":"johns-hopkins","kind":"institution","name":"Johns Hopkins Hospital / Sidney Kimmel Comprehensive Cancer Center","route":"/institutions/johns-hopkins/"},{"id":"lustgarten-foundation","kind":"institution","name":"Lustgarten Foundation","route":"/institutions/lustgarten-foundation/"}],"paper":[{"id":"paper-springer-pancreatic-cyst-molecular-classification-gastroenterology-2015","kind":"paper","name":"A combination of molecular markers and clinical features improve the classification of pancreatic cysts","route":"/key-papers/paper-springer-pancreatic-cyst-molecular-classification-gastroenterology-2015/"},{"id":"paper-fearon-cell","kind":"paper","name":"A genetic model for colorectal tumorigenesis","route":"/key-papers/paper-fearon-cell/"},{"id":"paper-vogelstein-cancer-genome-landscapes-science-2013","kind":"paper","name":"Cancer genome landscapes: about 140 driver genes, and each tumour needs only a handful","route":"/key-papers/paper-vogelstein-cancer-genome-landscapes-science-2013/"},{"id":"paper-tie-ctdna-minimal-residual-disease-stage-ii-colon-sci-transl-med-2016","kind":"paper","name":"Circulating tumor DNA analysis detects minimal residual disease and predicts recurrence in patients with stage II colon cancer","route":"/key-papers/paper-tie-ctdna-minimal-residual-disease-stage-ii-colon-sci-transl-med-2016/"},{"id":"paper-cohen-ctdna-protein-liquid-biopsy-pancreatic-pnas-2017","kind":"paper","name":"Combined circulating tumor DNA and protein biomarker-based liquid biopsy for the earlier detection of pancreatic cancers","route":"/key-papers/paper-cohen-ctdna-protein-liquid-biopsy-pancreatic-pnas-2017/"},{"id":"paper-jones-pancreatic-core-pathways-science-2008","kind":"paper","name":"Core signaling pathways in human pancreatic cancers revealed by global genomic analyses","route":"/key-papers/paper-jones-pancreatic-core-pathways-science-2008/"},{"id":"paper-detect-a-science-2020","kind":"paper","name":"DETECT-A: a blood test plus PET-CT found treatable cancers in 10,000 women with no symptoms","route":"/key-papers/paper-detect-a-science-2020/"},{"id":"paper-cohen-cancerseek-multi-analyte-blood-test-science-2018","kind":"paper","name":"Detection and localization of surgically resectable cancers with a multi-analyte blood test","route":"/key-papers/paper-cohen-cancerseek-multi-analyte-blood-test-science-2018/"},{"id":"paper-yachida-metastasis-late-genetic-evolution-pancreatic-nature-2010","kind":"paper","name":"Distant metastasis occurs late during the genetic evolution of pancreatic cancer","route":"/key-papers/paper-yachida-metastasis-late-genetic-evolution-pancreatic-nature-2010/"},{"id":"paper-dynamic-nejm-2022","kind":"paper","name":"DYNAMIC: a blood test safely halved chemotherapy use after surgery for stage II colon cancer","route":"/key-papers/paper-dynamic-nejm-2022/"},{"id":"paper-el-deiry-waf1-p21-cell-1993","kind":"paper","name":"El-Deiry 1993: WAF1, the gene through which p53 stops cell division","route":"/key-papers/paper-el-deiry-waf1-p21-cell-1993/"},{"id":"paper-vogelstein-genetic-alterations-colorectal-tumor-development-nejm-1988","kind":"paper","name":"Genetic alterations during colorectal-tumor development","route":"/key-papers/paper-vogelstein-genetic-alterations-colorectal-tumor-development-nejm-1988/"},{"id":"paper-lengauer-genetic-instability-colorectal-nature-1997","kind":"paper","name":"Genetic instability in colorectal cancers","route":"/key-papers/paper-lengauer-genetic-instability-colorectal-nature-1997/"},{"id":"paper-hollstein-p53-mutations-science-1991","kind":"paper","name":"Hollstein 1991: p53 mutations in human cancers","route":"/key-papers/paper-hollstein-p53-mutations-science-1991/"},{"id":"paper-markowitz-tgfbr2-inactivation-msi-colon-science-1995","kind":"paper","name":"Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability","route":"/key-papers/paper-markowitz-tgfbr2-inactivation-msi-colon-science-1995/"},{"id":"paper-herman-mlh1-promoter-hypermethylation-colorectal-pnas-1998","kind":"paper","name":"Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma","route":"/key-papers/paper-herman-mlh1-promoter-hypermethylation-colorectal-pnas-1998/"},{"id":"paper-le-mmr-deficiency-pd1-nejm-2015","kind":"paper","name":"Le 2015: PD-1 blockade works in tumours with mismatch-repair deficiency, whatever the organ","route":"/key-papers/paper-le-mmr-deficiency-pd1-nejm-2015/"},{"id":"paper-makohon-moore-metastases-driver-homogeneity-nat-genet-2017","kind":"paper","name":"Limited heterogeneity of known driver gene mutations among the metastases of individual patients with pancreatic cancer","route":"/key-papers/paper-makohon-moore-metastases-driver-homogeneity-nat-genet-2017/"},{"id":"paper-kanda-panin-1-somatic-mutations-gastroenterology-2012","kind":"paper","name":"Presence of somatic mutations in most early-stage pancreatic intraepithelial neoplasia","route":"/key-papers/paper-kanda-panin-1-somatic-mutations-gastroenterology-2012/"},{"id":"paper-wu-gnas-ipmn-sci-transl-med-2011","kind":"paper","name":"Recurrent GNAS mutations define an unexpected pathway for pancreatic cyst development","route":"/key-papers/paper-wu-gnas-ipmn-sci-transl-med-2011/"},{"id":"paper-diaz-molecular-evolution-egfr-resistance-colorectal-nature-2012","kind":"paper","name":"The molecular evolution of acquired resistance to targeted EGFR blockade in colorectal cancers","route":"/key-papers/paper-diaz-molecular-evolution-egfr-resistance-colorectal-nature-2012/"},{"id":"paper-vogelstein-surfing-p53-network-nature-2000","kind":"paper","name":"Vogelstein, Lane and Levine 2000: surfing the p53 network","route":"/key-papers/paper-vogelstein-surfing-p53-network-nature-2000/"},{"id":"paper-wu-pancreatic-cyst-exomes-rnf43-pnas-2011","kind":"paper","name":"Whole-exome sequencing of neoplastic cysts of the pancreas reveals recurrent mutations in components of ubiquitin-dependent pathways","route":"/key-papers/paper-wu-pancreatic-cyst-exomes-rnf43-pnas-2011/"}],"term":[{"id":"detect-a-study","kind":"term","name":"DETECT-A: a blood test plus PET-CT to screen 10,006 women with no symptoms","route":"/terms/detect-a-study/"},{"id":"driver-passenger-model","kind":"term","name":"Driver and passenger mutations: the refined somatic mutation theory","route":"/terms/driver-passenger-model/"},{"id":"somatic-mutation-theory","kind":"term","name":"Somatic mutation theory of cancer","route":"/terms/somatic-mutation-theory/"}],"roadmap":[{"id":"colorectal-roadmap","kind":"roadmap","name":"Colorectal cancer roadmap: from the adenoma-carcinoma sequence and the first screening trials to total mesorectal excision, oxaliplatin, RAS testing, immunotherapy for mismatch repair-deficient disease, ctDNA-guided treatment and organ preservation","route":"/roadmaps/colorectal-roadmap/"}],"pathway":[{"id":"theories-of-cancer","kind":"pathway","name":"Theories of cancer: how the ideas connect","route":"/pathways/theories-of-cancer/"}]}}