{"entity":{"id":"bcor","kind":"target","name":"BCOR","aka":["BCL6 corepressor","BCL-6 corepressor","FLJ20285","KIAA1575"],"tldr":"BCOR (BCL-6 corepressor) is a protein that switches other genes on and off. The public catalogues list it as an oncogene driver, a tumour suppressor and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Leukaemia, Non-Hodgkin lymphoma, Endometrial cancer and 5 more.","summary":"Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence-specific DNA-binding proteins such as BCL6 and MLLT3. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor.\n\nCIViC holds 13 clinical evidence items and 4 assertions across 2 variants. Open Targets scores its association with cancer at 0.80 (direct and indirect evidence; datatypes literature 0.95, affected pathway 0.61, genetic association 0.52, somatic mutation 0.91). IntOGen calls it a driver in 23 cohorts (5 activating, 18 loss-of-function), covering Adrenocortical Carcinoma, Acute Myeloid Leukaemia, Cholangiocarcinoma, Chronic Lymphocytic Leukaemia/Small Lymphocytic Lymphoma, Colorectal Adenocarcinoma, Glioblastoma Multiforme and others.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:20893","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:20893"},{"label":"UniProt Q6W2J9","url":"https://www.uniprot.org/uniprotkb/Q6W2J9/entry"},{"label":"NCBI Gene 54880","url":"https://www.ncbi.nlm.nih.gov/gene/54880"},{"label":"Ensembl ENSG00000183337","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000183337"}],"tags":["cancer-genes-wave"],"related":["civic","open-targets","intogen"],"cancers":["leukaemia","non-hodgkin-lymphoma","endometrial","gastric","sarcoma","mds","colorectal","adrenocortical"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 5 cohorts; IntOGen calls it a loss-of-function (LoF) driver in 18 cohorts; CIViC holds 13 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate.","Diseases the sources name that have no OnCo cancer page yet, so they are not linked: Kidney Clear Cell Sarcoma; Central Nervous System Tumour With BCOR Internal Tandem Duplication; Low-Grade Glioma, NOS."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"BCOR","role":["oncogene-driver","tumour-suppressor","biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:20893","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:20893","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q6W2J9","url":"https://www.uniprot.org/uniprotkb/Q6W2J9/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene BCOR","url":"https://civicdb.org/features/12555","note":"13 evidence items, 4 assertions, 2 variants; diseases: Kidney Clear Cell Sarcoma, Central Nervous System Tumour With BCOR Internal Tandem Duplication, Sarcoma, Stomach Cancer, Myelodysplastic Syndrome (GraphQL API, CC0)"},{"label":"Open Targets ENSG00000183337","url":"https://platform.opentargets.org/target/ENSG00000183337/associations","note":"association with cancer (MONDO_0004992) 0.80; per-cancer scores at or above 0.5: colorectal cancer 0.59, gastric cancer 0.51, endometrial cancer 0.62, melanoma 0.55, acute myeloid leukaemia 0.54, acute lymphoblastic leukaemia 0.61 (GraphQL API, CC0)"},{"label":"IntOGen BCOR","url":"https://www.intogen.org/search?gene=BCOR","note":"driver in 23 cohorts (Act 5, LoF 18); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"specificity":"tumour-specific","distribution":"many-types","specificityNote":"Tumour-specific alteration: the catalogues call it an oncogene driver (IntOGen cohort analysis finds it activated more often than chance) and a tumour suppressor (IntOGen finds it knocked out more often than chance), so the direction differs between cohorts but the alteration is somatic either way; what a medicine would aim at or exploit is the altered form or its loss, absent from normal cells; no corpus medicine is aimed at it yet. HPA BCOR: RNA low tissue specificity; no normal tissue stained high. Distribution: 8 cancer families in the corpus carry a prevalence row, label threshold or catalogue link for it (Leukaemia, Lymphoma, Endometrial cancer, Gastric & gastro-oesophageal junction cancer, Sarcomas (soft tissue, bone, GIST), Myeloid neoplasms, Colorectal cancer and more); Open Targets associates it with 0 specific cancer types at or above 0.5. (Rule 6 of scripts/fetch-target-specificity.ts.)","specificitySources":[{"label":"UniProt Q6W2J9","url":"https://www.uniprot.org/uniprotkb/Q6W2J9/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene BCOR","url":"https://civicdb.org/features/12555","note":"13 evidence items, 4 assertions, 2 variants; diseases: Kidney Clear Cell Sarcoma, Central Nervous System Tumour With BCOR Internal Tandem Duplication, Sarcoma, Stomach Cancer, Myelodysplastic Syndrome (GraphQL API, CC0)"},{"label":"IntOGen BCOR","url":"https://www.intogen.org/search?gene=BCOR","note":"driver in 23 cohorts (Act 5, LoF 18); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"},{"label":"Human Protein Atlas BCOR tissue","url":"https://www.proteinatlas.org/ENSG00000183337-BCOR/tissue","note":"RNA tissue and blood lineage specificity, normal tissue antibody staining (version 25.1, CC BY-SA 3.0)"},{"label":"Open Targets ENSG00000183337 associations","url":"https://platform.opentargets.org/target/ENSG00000183337/associations","note":"cancer associations at or above 0.5 (CC0)"}],"hgnc":"HGNC:20893","ensembl":"ENSG00000183337","uniprot":"Q6W2J9","entrez":"54880","firstDescribed":2000,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: Huynh K.D. et al, Genes Dev, 2000, \"BCoR, a novel corepressor involved in BCL-6 repression\".","firstDescribedSource":"https://pubmed.ncbi.nlm.nih.gov/10898795/","biology":"Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence-specific DNA-binding proteins such as BCL6 and MLLT3. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor. Involved in the repression of TFAP2A; impairs binding of BCL6 and KDM2B to TFAP2A promoter regions. Via repression of TFAP2A acts as a negative regulator of osteo-dentiogenic capacity in adult stem cells; the function implies inhibition of methylation on histone H3 'Lys-4' (H3K4me3) and 'Lys-36' (H3K36me2). Location: Nucleus (UniProt). Locus Xp11.4 (HGNC).","whereFound":["Leukaemia: Open Targets association 0.69 with leukaemia (MONDO_0005059)","Non-Hodgkin lymphoma: Open Targets association 0.63 with non-Hodgkin lymphoma (MONDO_0018908)","Endometrial cancer: Open Targets association 0.62 with endometrial cancer (MONDO_0011962); IntOGen driver in 3 cohorts (UCEC)","Gastric & gastro-oesophageal junction cancer: Open Targets association 0.51 with gastric cancer (MONDO_0001056); CIViC evidence names this disease","Sarcomas: CIViC evidence names this disease","Myelodysplastic syndromes / neoplasms: CIViC evidence names this disease"],"targetClass":"transcription","prevalence":[]},"route":"/targets/bcor/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"},{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"adrenocortical","kind":"cancer","name":"Adrenocortical carcinoma","route":"/cancers/adrenocortical/"},{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"},{"id":"endometrial","kind":"cancer","name":"Endometrial cancer","route":"/cancers/endometrial/"},{"id":"gastric","kind":"cancer","name":"Gastric & gastro-oesophageal junction cancer","route":"/cancers/gastric/"},{"id":"leukaemia","kind":"cancer","name":"Leukaemia (all types)","route":"/cancers/leukaemia/"},{"id":"mds","kind":"cancer","name":"Myelodysplastic syndromes / neoplasms (MDS)","route":"/cancers/mds/"},{"id":"non-hodgkin-lymphoma","kind":"cancer","name":"Non-Hodgkin lymphoma (all types)","route":"/cancers/non-hodgkin-lymphoma/"},{"id":"sarcoma","kind":"cancer","name":"Sarcomas (soft tissue, bone, GIST)","route":"/cancers/sarcoma/"}]}}