{"entity":{"id":"barretts-esophagus","kind":"term","name":"Barrett's oesophagus","aka":["Barrett's","Barrett","Barrett's esophagus","Barrett oesophagus","Barrett's metaplasia","intestinal metaplasia","barretts-oesophagus"],"tldr":"A change in the lining of the lower oesophagus caused by acid reflux that can, in a minority, progress through dysplasia to adenocarcinoma. It is why Western oesophageal cancer is mostly adenocarcinoma.","summary":"Intestinal metaplasia of the distal oesophagus in ~1-2% of adults; annual progression to adenocarcinoma ~0.1-0.3%, higher with dysplasia. Surveillance endoscopy, radiofrequency ablation and endoscopic resection for dysplasia, and proton-pump inhibitors (AspECT) reduce progression. Non-endoscopic screening (Cytosponge, capsule sponge) is being evaluated for population use.","asOf":"2026-09-07","wikipedia":"https://en.wikipedia.org/wiki/Barrett%27s_esophagus","links":[{"label":"Wikipedia","url":"https://en.wikipedia.org/wiki/Barrett%27s_esophagus"}],"tags":[],"related":["dysplasia","endoscopic-resection","radiofrequency-ablation","gej"],"cancers":["esophageal"],"sections":["early-detection"],"technologies":["endoscopic-resection","chemoprevention"],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"category":"Cancer biology"},"route":"/terms/barretts-esophagus/","neighbours":{"term":[{"id":"dysplasia","kind":"term","name":"Dysplasia (pre-cancerous change)","route":"/terms/dysplasia/"},{"id":"endoscopic-resection-term","kind":"term","name":"EMR and ESD (endoscopic mucosal resection, endoscopic submucosal dissection)","route":"/terms/endoscopic-resection-term/"},{"id":"gej","kind":"term","name":"Gastro-oesophageal junction (GEJ)","route":"/terms/gej/"},{"id":"radiofrequency-ablation","kind":"term","name":"Radiofrequency ablation (RFA)","route":"/terms/radiofrequency-ablation/"},{"id":"escc-vs-eac","kind":"term","name":"Squamous cell carcinoma vs adenocarcinoma of the oesophagus","route":"/terms/escc-vs-eac/"}],"technology":[{"id":"chemoprevention","kind":"technology","name":"Chemoprevention & risk-reducing surgery","route":"/technologies/chemoprevention/"},{"id":"endoscopic-resection","kind":"technology","name":"Endoscopic resection (EMR / ESD)","route":"/technologies/endoscopic-resection/"}],"cancer":[{"id":"esophageal","kind":"cancer","name":"Oesophageal cancer","route":"/cancers/esophageal/"}],"section":[{"id":"early-detection","kind":"section","name":"Early Detection & Screening","route":"/fronts/early-detection/"}],"idea":[{"id":"idea-field-interception","kind":"idea","name":"Intercept cancer at the field stage","route":"/ideas/idea-field-interception/"},{"id":"idea-non-endoscopic-barretts-screening","kind":"idea","name":"Non-endoscopic screening for Barrett's oesophagus and early adenocarcinoma","route":"/ideas/idea-non-endoscopic-barretts-screening/"}],"bottleneck":[{"id":"b-early-detection","kind":"bottleneck","name":"The hardest cancers are found late","route":"/bottlenecks/b-early-detection/"}],"pathway":[{"id":"basement-membrane-tissue-barriers","kind":"pathway","name":"Basement membrane & tissue barriers","route":"/pathways/basement-membrane-tissue-barriers/"},{"id":"field-cancerisation","kind":"pathway","name":"Field cancerisation","route":"/pathways/field-cancerisation/"}]}}