{"entity":{"id":"atp1a1","kind":"target","name":"ATP1A1","aka":["ATPase Na+/K+ transporting subunit alpha 1","Sodium/potassium-transporting ATPase subunit alpha-1"],"tldr":"ATP1A1 (Sodium/potassium-transporting ATPase subunit alpha-1) is a gene that drives cell growth when it is altered. The public catalogues list it as a drug target and an oncogene driver, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Breast cancer, Gastric & gastro-oesophageal junction cancer and Colorectal cancer.","summary":"Catalytic subunit of the Na(+)/K(+)-ATPase pump that hydrolyses ATP to exchange ions across the plasma membrane, exporting 3 Na(+) and importing 2 K(+) per cycle against electrochemical gradients. It undergoes ATP-driven conformational changes that allow alternating binding and release of Na(+) and K(+) ions across the membrane. This process maintains essential Na(+) and K(+) gradients for membrane potential and cellular function.\n\nOpen Targets scores its association with cancer at 0.67 (direct and indirect evidence; datatypes clinical 0.18, affected pathway 0.32, literature 0.95, genetic association 0.00, somatic mutation 0.77). IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Invasive Breast Carcinoma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:799","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:799"},{"label":"UniProt P05023","url":"https://www.uniprot.org/uniprotkb/P05023/entry"},{"label":"NCBI Gene 476","url":"https://www.ncbi.nlm.nih.gov/gene/476"},{"label":"Ensembl ENSG00000163399","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000163399"}],"tags":["cancer-genes-wave"],"related":["open-targets","intogen"],"cancers":["breast-cancer","gastric","colorectal"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.18; IntOGen calls it an activating (Act) driver in 1 cohort. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"ATP1A1","role":["drug-target","oncogene-driver"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:799","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:799","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P05023","url":"https://www.uniprot.org/uniprotkb/P05023/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000163399","url":"https://platform.opentargets.org/target/ENSG00000163399/associations","note":"association with cancer (MONDO_0004992) 0.67; per-cancer scores at or above 0.5: colorectal cancer 0.50, gastric cancer 0.51 (GraphQL API, CC0)"},{"label":"IntOGen ATP1A1","url":"https://www.intogen.org/search?gene=ATP1A1","note":"driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"specificity":"tumour-specific","distribution":"few-types","specificityNote":"Tumour-specific alteration: the catalogues call it an oncogene driver (IntOGen cohort analysis finds it activated more often than chance); what a medicine would aim at or exploit is the altered form or its loss, absent from normal cells; no corpus medicine is aimed at it yet. HPA ATP1A1: RNA tissue enhanced (parathyroid gland 1,394 nTPM); high antibody staining in 19 normal tissues; highest cancer staining colorectal cancer (12 of 12 high). Distribution: 3 cancer families in the corpus carry a prevalence row, label threshold or catalogue link for it (Breast cancer (all types), Gastric & gastro-oesophageal junction cancer, Colorectal cancer); Open Targets associates it with 1 specific cancer type at or above 0.5 (aldosterone-producing adrenal cortex adenoma). (Rule 6 of scripts/fetch-target-specificity.ts.)","specificitySources":[{"label":"UniProt P05023","url":"https://www.uniprot.org/uniprotkb/P05023/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"IntOGen ATP1A1","url":"https://www.intogen.org/search?gene=ATP1A1","note":"driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"},{"label":"Human Protein Atlas ATP1A1 tissue","url":"https://www.proteinatlas.org/ENSG00000163399-ATP1A1/tissue","note":"RNA tissue and blood lineage specificity, normal tissue antibody staining (version 25.1, CC BY-SA 3.0)"},{"label":"Open Targets ENSG00000163399 associations","url":"https://platform.opentargets.org/target/ENSG00000163399/associations","note":"cancer associations at or above 0.5 (CC0)"}],"hgnc":"HGNC:799","ensembl":"ENSG00000163399","uniprot":"P05023","entrez":"476","firstDescribed":1986,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: Kawakami et al, J. Biochem, 1986, \"Primary structure of the alpha-subunit of human Na,K-ATPase deduced from cDNA sequence\".","firstDescribedSource":"https://pubmed.ncbi.nlm.nih.gov/2430951/","biology":"Catalytic subunit of the Na(+)/K(+)-ATPase pump that hydrolyses ATP to exchange ions across the plasma membrane, exporting 3 Na(+) and importing 2 K(+) per cycle against electrochemical gradients. It undergoes ATP-driven conformational changes that allow alternating binding and release of Na(+) and K(+) ions across the membrane. This process maintains essential Na(+) and K(+) gradients for membrane potential and cellular function. Could also be part of an osmosensory signalling pathway that senses body-fluid sodium levels and controls salt intake behaviour as well as voluntary water intake to regulate sodium homeostasis. Location: Cell membrane; Basolateral cell membrane; Cell membrane, sarcolemma; Cell projection, axon (UniProt). Locus 1p13.1 (HGNC).","whereFound":["Breast cancer: IntOGen driver in 1 cohort (BRCA)","Gastric & gastro-oesophageal junction cancer: Open Targets association 0.51 with gastric cancer (MONDO_0001056)","Colorectal cancer: Open Targets association 0.50 with colorectal cancer (MONDO_0005575)"],"targetClass":"oncogene","prevalence":[]},"route":"/targets/atp1a1/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"},{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"},{"id":"gastric","kind":"cancer","name":"Gastric & gastro-oesophageal junction cancer","route":"/cancers/gastric/"}]}}