{"entity":{"id":"atg7","kind":"target","name":"ATG7","aka":["autophagy related 7","Ubiquitin-like modifier-activating enzyme ATG7","GSA7","DKFZp434N0735","APG7L"],"tldr":"ATG7 (Ubiquitin-like modifier-activating enzyme ATG7) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Pancreatic ductal adenocarcinoma, Renal cell carcinoma and Clear cell renal cell carcinoma.","summary":"E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes.\n\nCIViC holds 1 clinical evidence item and 0 assertions across 1 variant. Open Targets scores its association with cancer at 0.64 (direct and indirect evidence; datatypes literature 0.98, affected pathway 0.89, genetic association 0.34, somatic mutation 0.36). IntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Renal Clear Cell Carcinoma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:16935","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:16935"},{"label":"UniProt O95352","url":"https://www.uniprot.org/uniprotkb/O95352/entry"},{"label":"NCBI Gene 10533","url":"https://www.ncbi.nlm.nih.gov/gene/10533"},{"label":"Ensembl ENSG00000197548","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000197548"}],"tags":["cancer-genes-wave"],"related":["civic","open-targets","intogen"],"cancers":["pancreatic","rcc","clear-cell-rcc"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 1 cohort; CIViC holds 1 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"ATG7","role":["tumour-suppressor","biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:16935","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:16935","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt O95352","url":"https://www.uniprot.org/uniprotkb/O95352/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene ATG7","url":"https://civicdb.org/features/8392","note":"1 evidence items, 0 assertions, 1 variants; diseases: Pancreatic Ductal Adenocarcinoma (GraphQL API, CC0)"},{"label":"Open Targets ENSG00000197548","url":"https://platform.opentargets.org/target/ENSG00000197548/associations","note":"association with cancer (MONDO_0004992) 0.64;  (GraphQL API, CC0)"},{"label":"IntOGen ATG7","url":"https://www.intogen.org/search?gene=ATG7","note":"driver in 1 cohort (Act 0, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"specificity":"tumour-specific","distribution":"few-types","specificityNote":"Tumour-specific alteration: the catalogues call it a tumour suppressor (IntOGen finds it knocked out more often than chance); what a medicine would aim at or exploit is the altered form or its loss, absent from normal cells; no corpus medicine is aimed at it yet. HPA ATG7: RNA low tissue specificity; high antibody staining in 2 normal tissues; highest cancer staining glioma (4 of 10 high). Distribution: 2 cancer families in the corpus carry a prevalence row, label threshold or catalogue link for it (Pancreatic ductal adenocarcinoma, Renal cell carcinoma); Open Targets associates it with 0 specific cancer types at or above 0.5. (Rule 6 of scripts/fetch-target-specificity.ts.)","specificitySources":[{"label":"UniProt O95352","url":"https://www.uniprot.org/uniprotkb/O95352/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene ATG7","url":"https://civicdb.org/features/8392","note":"1 evidence items, 0 assertions, 1 variants; diseases: Pancreatic Ductal Adenocarcinoma (GraphQL API, CC0)"},{"label":"IntOGen ATG7","url":"https://www.intogen.org/search?gene=ATG7","note":"driver in 1 cohort (Act 0, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"},{"label":"Human Protein Atlas ATG7 tissue","url":"https://www.proteinatlas.org/ENSG00000197548-ATG7/tissue","note":"RNA tissue and blood lineage specificity, normal tissue antibody staining (version 25.1, CC BY-SA 3.0)"},{"label":"Open Targets ENSG00000197548 associations","url":"https://platform.opentargets.org/target/ENSG00000197548/associations","note":"cancer associations at or above 0.5 (CC0)"}],"hgnc":"HGNC:16935","ensembl":"ENSG00000197548","uniprot":"O95352","entrez":"10533","firstDescribed":1999,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: Yuan et al, Mol. Biol. Cell, 1999, \"Glucose-induced autophagy of peroxisomes in Pichia pastoris requires a unique E1-like protein\".","firstDescribedSource":"https://pubmed.ncbi.nlm.nih.gov/10233149/","biology":"E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Facilitates LC3-I lipidation with phosphatidylethanolamine to form LC3-II which is found on autophagosomal membranes. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Location: Cytoplasm; Preautophagosomal structure (UniProt). Locus 3p25.3 (HGNC).","whereFound":["Pancreatic ductal adenocarcinoma: CIViC evidence names this disease","Renal cell carcinoma: IntOGen driver in 1 cohort (CCRCC)","Clear cell renal cell carcinoma: IntOGen driver in 1 cohort (CCRCC)"],"targetClass":"tumor-suppressor","prevalence":[]},"route":"/targets/atg7/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"},{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"clear-cell-rcc","kind":"cancer","name":"Clear cell renal cell carcinoma","route":"/cancers/clear-cell-rcc/"},{"id":"pancreatic","kind":"cancer","name":"Pancreatic ductal adenocarcinoma","route":"/cancers/pancreatic/"},{"id":"rcc","kind":"cancer","name":"Renal cell carcinoma","route":"/cancers/rcc/"}]}}