{"entity":{"id":"asns","kind":"target","name":"ASNS","aka":["asparagine synthetase (glutamine-hydrolyzing)","Asparagine synthetase [glutamine-hydrolyzing]"],"tldr":"ASNS (Asparagine synthetase [glutamine-hydrolysing]) is an enzyme. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Ovarian cancer.","summary":"Catalyses the ATP-dependent synthesis of L-asparagine from L-aspartate, using L-glutamine as a source of nitrogen. Can also use ammonia as the nitrogen source in vitro.\n\nCIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Asparaginase.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:753","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:753"},{"label":"UniProt P08243","url":"https://www.uniprot.org/uniprotkb/P08243/entry"},{"label":"NCBI Gene 440","url":"https://www.ncbi.nlm.nih.gov/gene/440"},{"label":"Ensembl ENSG00000070669","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000070669"}],"tags":["cancer-genes-wave"],"related":["civic"],"cancers":["ovarian"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 1 therapies; CIViC holds 1 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"ASNS","role":["drug-target","biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:753","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:753","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P08243","url":"https://www.uniprot.org/uniprotkb/P08243/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene ASNS","url":"https://civicdb.org/features/446","note":"1 evidence items, 0 assertions, 1 variants; diseases: Ovarian Cancer (GraphQL API, CC0)"}],"distribution":"one-type","specificityNote":"Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the roles drug-target, biomarker; HPA finds the RNA tissue enhanced, which says where the protein sits but not whether the tumour differs from normal tissue. HPA ASNS: RNA tissue enhanced (pancreas 114 nTPM); blood lineage group enriched (B-cells 9 nTPM, T-cells 14 nTPM); high antibody staining in 5 normal tissues; highest cancer staining colorectal cancer (3 of 11 high). Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Ovarian cancer); Open Targets associates it with 0 specific cancer types at or above 0.5. (No rule of scripts/fetch-target-specificity.ts fired.)","specificitySources":[{"label":"Human Protein Atlas ASNS tissue","url":"https://www.proteinatlas.org/ENSG00000070669-ASNS/tissue","note":"RNA tissue and blood lineage specificity, normal tissue antibody staining (version 25.1, CC BY-SA 3.0)"},{"label":"Open Targets ENSG00000070669 associations","url":"https://platform.opentargets.org/target/ENSG00000070669/associations","note":"cancer associations at or above 0.5 (CC0)"}],"hgnc":"HGNC:753","ensembl":"ENSG00000070669","uniprot":"P08243","entrez":"440","firstDescribed":1987,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: Andrulis I.L. et al, Mol. Cell. Biol, 1987, \"Isolation of human cDNAs for asparagine synthetase and expression in Jensen rat sarcoma cells\".","firstDescribedSource":"https://pubmed.ncbi.nlm.nih.gov/2886907/","biology":"Catalyses the ATP-dependent synthesis of L-asparagine from L-aspartate, using L-glutamine as a source of nitrogen. Can also use ammonia as the nitrogen source in vitro. Locus 7q21.3 (HGNC).","whereFound":["Ovarian cancer: CIViC evidence names this disease"],"targetClass":"enzyme","prevalence":[]},"route":"/targets/asns/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"}],"cancer":[{"id":"ovarian","kind":"cancer","name":"Ovarian cancer","route":"/cancers/ovarian/"}]}}