{"entity":{"id":"asher-bio","kind":"company","name":"Asher Biotherapeutics","aka":[],"tldr":"Asher Bio engineers immune-stimulating molecules that switch on only one type of immune cell, such as killer T cells, so the drug is more potent against tumours and causes fewer side effects.","summary":"Asher Biotherapeutics builds cis-targeted immunotherapies: a cytokine fused to an antibody arm that binds a marker on the intended cell type, so the cytokine acts selectively rather than on every cell bearing its receptor. The lead programme AB248 is a CD8-targeted interleukin-2 in phase 1 for advanced solid tumours, alone and with pembrolizumab; a second programme targets regulatory T cells for autoimmune disease. The company was founded with Third Rock Ventures, went through YC, and has raised Series A and B rounds; amounts are not recorded here because no primary source was fetched.","asOf":"2026-09-10","links":[{"label":"Y Combinator profile","url":"https://www.ycombinator.com/companies/asher-bio"},{"label":"Official website","url":"https://www.asherbio.com"}],"tags":["yc"],"related":[],"cancers":["rcc","melanoma"],"sections":["immunotherapy"],"technologies":["cytokine-therapy"],"targets":["cd3"],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"hq":"South San Francisco, CA","country":"US","companyType":"biotech","website":"https://www.asherbio.com","stage":"growth","ycBatch":"S19","investors":["y-combinator","third-rock-ventures"],"funding":[]},"route":"/companies/asher-bio/","neighbours":{"cancer":[{"id":"melanoma","kind":"cancer","name":"Melanoma","route":"/cancers/melanoma/"},{"id":"rcc","kind":"cancer","name":"Renal cell carcinoma","route":"/cancers/rcc/"}],"section":[{"id":"immunotherapy","kind":"section","name":"Immunotherapy","route":"/fronts/immunotherapy/"}],"technology":[{"id":"cytokine-therapy","kind":"technology","name":"Cytokines & engineered cytokines","route":"/technologies/cytokine-therapy/"}],"target":[{"id":"cd3","kind":"target","name":"CD3","route":"/targets/cd3/"}],"company":[{"id":"third-rock-ventures","kind":"company","name":"Third Rock Ventures","route":"/companies/third-rock-ventures/"},{"id":"y-combinator","kind":"company","name":"Y Combinator","route":"/companies/y-combinator/"}]}}