{"entity":{"id":"arul-chinnaiyan","kind":"person","name":"Arul M. Chinnaiyan","aka":[],"tldr":"Discovered the TMPRSS2-ERG fusion in prostate cancer and built one of the first clinical sequencing programmes.","summary":"Arul M. Chinnaiyan is Director of the Michigan Center for Translational Pathology, S.P. Hicks Professor of Pathology and an HHMI Investigator at the University of Michigan Rogel Cancer Center. He is a pathologist-scientist known for discovering the TMPRSS2-ERG gene fusion in prostate cancer in 2005 and for building one of the first clinical sequencing programmes, MI-ONCOSEQ. His selected papers report recurrent fusion of TMPRSS2 and ETS transcription factor genes in prostate cancer, and integrative clinical genomics of advanced prostate cancer. He continues to work on comprehensive genomic profiling, long non-coding RNA and urine-based prostate cancer diagnostics.","asOf":"2026-09-08","links":[{"label":"Michigan profile","url":"https://www.pathology.med.umich.edu/faculty/arul"},{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Chinnaiyan%20AM%5BAuthor%5D"}],"tags":[],"related":[],"cancers":["prostate"],"sections":[],"technologies":["cgp","rna-seq"],"targets":[],"drugs":[],"companies":[],"institutions":["michigan-rogel"],"pathways":[],"terms":["gene-fusion"],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"role":"Director, Michigan Center for Translational Pathology; S.P. Hicks Professor of Pathology; HHMI Investigator","institutionId":"michigan-rogel","specialisms":["Prostate cancer genomics","Gene fusions","Precision oncology sequencing","Long non-coding RNA"],"profiles":[{"label":"Michigan profile","url":"https://www.pathology.med.umich.edu/faculty/arul"},{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Chinnaiyan%20AM%5BAuthor%5D"}],"papers":[{"title":"Recurrent fusion of TMPRSS2 and ETS transcription factor genes in prostate cancer","journal":"Science","year":2005,"url":"https://doi.org/10.1126/science.1117679","doi":"10.1126/science.1117679"},{"title":"Integrative clinical genomics of advanced prostate cancer","journal":"Cell","year":2015,"url":"https://doi.org/10.1016/j.cell.2015.05.001","doi":"10.1016/j.cell.2015.05.001"}],"orcid":"0000-0001-9282-3415"},"route":"/people/arul-chinnaiyan/","neighbours":{"cancer":[{"id":"prostate","kind":"cancer","name":"Prostate cancer","route":"/cancers/prostate/"}],"technology":[{"id":"cgp","kind":"technology","name":"Comprehensive genomic profiling","route":"/technologies/cgp/"},{"id":"rna-seq","kind":"technology","name":"RNA sequencing & expression profiling","route":"/technologies/rna-seq/"}],"institution":[{"id":"michigan-rogel","kind":"institution","name":"University of Michigan Rogel Cancer Center","route":"/institutions/michigan-rogel/"}],"term":[{"id":"gene-fusion","kind":"term","name":"Gene fusion","route":"/terms/gene-fusion/"}],"paper":[{"id":"paper-tomlins-tmprss2-ets-fusion-science-2005","kind":"paper","name":"Recurrent fusion of TMPRSS2 and ETS transcription factor genes in prostate cancer","route":"/key-papers/paper-tomlins-tmprss2-ets-fusion-science-2005/"},{"id":"paper-robinson-integrative-clinical-genomics-advanced-prostate-cell-2015","kind":"paper","name":"SU2C-PCF: integrative clinical genomics of advanced prostate cancer","route":"/key-papers/paper-robinson-integrative-clinical-genomics-advanced-prostate-cell-2015/"},{"id":"paper-grasso-mutational-landscape-lethal-crpc-nature-2012","kind":"paper","name":"The mutational landscape of lethal castration-resistant prostate cancer","route":"/key-papers/paper-grasso-mutational-landscape-lethal-crpc-nature-2012/"}]}}