{"entity":{"id":"arpeggio-bio","kind":"company","name":"Arpeggio Bio","aka":[],"tldr":"Arpeggio Bio uses AI on large RNA-sequencing datasets to find drugs against transcription factors, the hard-to-hit proteins that switch cancer genes on, with a first programme in immunotherapy-resistant melanoma.","summary":"Arpeggio Bio combines high-throughput RNA sequencing with machine learning to discover small molecules that modulate transcription factors long considered undruggable, naming NRF2, TEAD and GPX4 among its targets. Its YC profile states that its lead programme was progressing towards a development candidate for melanoma resistant to checkpoint inhibitors and that the company had about $20 million in venture funding and partnerships with Johnson & Johnson and FORMA Therapeutics; those figures are the company's own and are not repeated as a funding row here. The company website returned an error when checked on 2026-09-10.","asOf":"2026-09-10","links":[{"label":"Y Combinator profile","url":"https://www.ycombinator.com/companies/arpeggio-bio"}],"tags":["yc"],"related":[],"cancers":["melanoma"],"sections":["drug-discovery","targeted-therapy"],"technologies":["ai-drug-design","rna-seq"],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"hq":"Boulder, CO","country":"US","companyType":"biotech","website":"https://www.ycombinator.com/companies/arpeggio-bio","stage":"startup","ycBatch":"S19","investors":["y-combinator"],"funding":[]},"route":"/companies/arpeggio-bio/","neighbours":{"cancer":[{"id":"melanoma","kind":"cancer","name":"Melanoma","route":"/cancers/melanoma/"}],"section":[{"id":"drug-discovery","kind":"section","name":"Drug Discovery Platforms","route":"/fronts/drug-discovery/"},{"id":"targeted-therapy","kind":"section","name":"Targeted Therapy","route":"/fronts/targeted-therapy/"}],"technology":[{"id":"ai-drug-design","kind":"technology","name":"AI-driven drug & target discovery","route":"/technologies/ai-drug-design/"},{"id":"rna-seq","kind":"technology","name":"RNA sequencing & expression profiling","route":"/technologies/rna-seq/"}],"company":[{"id":"y-combinator","kind":"company","name":"Y Combinator","route":"/companies/y-combinator/"}],"roadmap":[{"id":"epigenetics-roadmap","kind":"roadmap","name":"Epigenetic therapy roadmap: loosening silenced genes → mutation-specific enzymes → editing the epigenome","route":"/roadmaps/epigenetics-roadmap/"}]}}