{"entity":{"id":"arhgef10l","kind":"target","name":"ARHGEF10L","aka":["Rho guanine nucleotide exchange factor 10 like","Rho guanine nucleotide exchange factor 10-like protein","FLJ10521","KIAA1626"],"tldr":"ARHGEF10L (Rho guanine nucleotide exchange factor 10-like protein) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Renal cell carcinoma, Basal cell carcinoma and Clear cell renal cell carcinoma.","summary":"Acts as a guanine nucleotide exchange factor (GEF) for RHOA, RHOB and RHOC.\n\nIntOGen calls it a driver in 2 cohorts (0 activating, 2 loss-of-function), covering Basal Cell Carcinoma, Renal Clear Cell Carcinoma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:25540","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:25540"},{"label":"UniProt Q9HCE6","url":"https://www.uniprot.org/uniprotkb/Q9HCE6/entry"},{"label":"NCBI Gene 55160","url":"https://www.ncbi.nlm.nih.gov/gene/55160"},{"label":"Ensembl ENSG00000074964","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000074964"}],"tags":["cancer-genes-wave"],"related":["intogen"],"cancers":["rcc","basal-cell-carcinoma","clear-cell-rcc"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 2 cohorts. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"ARHGEF10L","role":["tumour-suppressor"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:25540","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:25540","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q9HCE6","url":"https://www.uniprot.org/uniprotkb/Q9HCE6/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"IntOGen ARHGEF10L","url":"https://www.intogen.org/search?gene=ARHGEF10L","note":"driver in 2 cohorts (Act 0, LoF 2); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"specificitySources":[],"hgnc":"HGNC:25540","ensembl":"ENSG00000074964","uniprot":"Q9HCE6","entrez":"55160","firstDescribed":2000,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: Nagase et al, DNA Res, 2000, \"Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro\".","firstDescribedSource":"https://pubmed.ncbi.nlm.nih.gov/10997877/","biology":"Acts as a guanine nucleotide exchange factor (GEF) for RHOA, RHOB and RHOC. Location: Cytoplasm (UniProt). Locus 1p36.13 (HGNC).","whereFound":["Renal cell carcinoma: IntOGen driver in 1 cohort (CCRCC)","Basal cell carcinoma: IntOGen driver in 1 cohort (BCC)","Clear cell renal cell carcinoma: IntOGen driver in 1 cohort (CCRCC)"],"targetClass":"tumor-suppressor","prevalence":[]},"route":"/targets/arhgef10l/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"}],"cancer":[{"id":"basal-cell-carcinoma","kind":"cancer","name":"Basal cell carcinoma","route":"/cancers/basal-cell-carcinoma/"},{"id":"clear-cell-rcc","kind":"cancer","name":"Clear cell renal cell carcinoma","route":"/cancers/clear-cell-rcc/"},{"id":"rcc","kind":"cancer","name":"Renal cell carcinoma","route":"/cancers/rcc/"}]}}