{"entity":{"id":"angela-lamarca","kind":"person","name":"Angela Lamarca","aka":[],"tldr":"Oncologist who was lead author of ABC-06, the first randomised trial to show that second-line chemotherapy helps people with advanced bile duct cancer.","summary":"Angela Lamarca trained and worked at The Christie in Manchester before moving to Madrid. She was first author of the 2021 Lancet Oncology report of ABC-06, the UK trial that showed FOLFOX plus active symptom control lengthened survival compared with symptom control alone after gemcitabine and cisplatin in advanced biliary tract cancer, establishing a second-line standard. She also works on neuroendocrine tumours.","asOf":"2026-09-18","links":[],"tags":["biliary","trialist"],"related":[],"cancers":["cholangiocarcinoma","biliary-tract-cancer","neuroendocrine"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":["abc-06"],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"role":"Medical oncologist, biliary tract and neuroendocrine cancers","specialisms":["Biliary tract cancer","Neuroendocrine tumours","Second-line chemotherapy"],"profiles":[{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Lamarca%5BAuthor%5D"}],"papers":[]},"route":"/people/angela-lamarca/","neighbours":{"cancer":[{"id":"biliary-tract-cancer","kind":"cancer","name":"Biliary tract cancer (all types)","route":"/cancers/biliary-tract-cancer/"},{"id":"cholangiocarcinoma","kind":"cancer","name":"Biliary tract cancer (cholangiocarcinoma)","route":"/cancers/cholangiocarcinoma/"},{"id":"neuroendocrine","kind":"cancer","name":"Neuroendocrine tumours","route":"/cancers/neuroendocrine/"}],"trial":[{"id":"abc-06","kind":"trial","name":"ABC-06","route":"/trials/abc-06/"}],"paper":[{"id":"paper-galdy-her2-biliary-tract-meta-analysis-cancer-metastasis-rev-2017","kind":"paper","name":"HER2/HER3 pathway in biliary tract malignancies; systematic review and meta-analysis: a potential therapeutic target?","route":"/key-papers/paper-galdy-her2-biliary-tract-meta-analysis-cancer-metastasis-rev-2017/"},{"id":"paper-abc-06-folfox-second-line-lancet-oncol-2021","kind":"paper","name":"Second-line FOLFOX chemotherapy versus active symptom control for advanced biliary tract cancer (ABC-06): a phase 3, open-label, randomised, controlled trial","route":"/key-papers/paper-abc-06-folfox-second-line-lancet-oncol-2021/"}],"roadmap":[{"id":"gallbladder-cancer-roadmap","kind":"roadmap","name":"Gallbladder cancer roadmap: from a chance finding at gallstone surgery to a disease with its own trials","route":"/roadmaps/gallbladder-cancer-roadmap/"}]}}