{"entity":{"id":"andrew-mesecar","kind":"person","name":"Andrew Mesecar","aka":[],"tldr":"Structural biologist who directs the Purdue Institute for Cancer Research, an NCI-designated basic science cancer centre in West Lafayette, Indiana.","summary":"Andrew Mesecar is the Robert W. Miller Director of the Purdue Institute for Cancer Research (PICR), one of only seven NCI-designated basic science cancer centres in the United States. He is Distinguished Professor of Biochemistry, Walther Professor of Cancer Structural Biology and Assistant Vice President for Research at Purdue University, and a member of the institute's Targets, Structures and Drugs programme. The institute's directory lists him at the head of a senior leadership team that includes deputy director Andrea Kasinski, associate directors Deborah Knapp and Dorothy Teegarden and senior managing director Douglas Cuttell. PICR describes its mission as promoting basic discovery, transdisciplinary collaboration and an improved drug discovery pipeline.","asOf":"2026-09-10","links":[{"label":"Source: Purdue Institute for Cancer Research directory (senior leadership)","url":"https://cancer.research.purdue.edu/directory/"}],"tags":["leadership","research-institute"],"related":[],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":["purdue-cancer-research"],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":["molecular-cancer-research"],"dependsOn":[],"notes":[],"role":"Robert W. Miller Director, Purdue Institute for Cancer Research","institutionId":"purdue-cancer-research","specialisms":["Structural biology","Biochemistry","Drug discovery"],"profiles":[{"label":"PICR directory profile","url":"https://cancer.research.purdue.edu/directory/andrew-mesecar/"},{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Mesecar+AD%5BAuthor%5D"}],"papers":[{"title":"Structural Basis for Tumor Pyruvate Kinase M2 Allosteric Regulation and Catalysis ,","journal":"Biochemistry","year":2005,"doi":"10.1021/bi0474923"},{"title":"Steady-state kinetic studies reveal that the anti-cancer target Ubiquitin-Specific Protease 17 (USP17) is a highly efficient deubiquitinating enzyme","journal":"Archives of Biochemistry and Biophysics","year":2016,"doi":"10.1016/j.abb.2016.10.008"},{"title":"Cholesterol Sulfonation Enzyme, SULT2B1b, Modulates AR and Cell Growth Properties in Prostate Cancer","journal":"Molecular Cancer Research","year":2016,"doi":"10.1158/1541-7786.mcr-16-0137"}],"orcid":"0000-0002-1241-2577"},"route":"/people/andrew-mesecar/","neighbours":{"institution":[{"id":"purdue-cancer-research","kind":"institution","name":"Purdue Institute for Cancer Research","route":"/institutions/purdue-cancer-research/"}],"journal":[{"id":"molecular-cancer-research","kind":"journal","name":"Molecular cancer research","route":"/journals/molecular-cancer-research/"}]}}