{"entity":{"id":"amar-gajjar","kind":"person","name":"Amar Gajjar","aka":[],"tldr":"Led the St. Jude medulloblastoma trials that introduced molecular subgroups into risk-adapted treatment.","summary":"Amar Gajjar led SJMB96 and SJMB03, the St. Jude medulloblastoma trials that established risk-adapted craniospinal radiotherapy with dose-intensive chemotherapy and showed how WNT, SHH and group 3/4 subgroups predict outcome, and SJMB12, the first trial to assign treatment by molecular subgroup. He co-chairs the Children's Oncology Group CNS committee and directs neuro-oncology at St. Jude.","asOf":"2026-09-10","links":[{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Gajjar%20A%5BAuthor%5D%20medulloblastoma"}],"tags":["paediatric","medulloblastoma","st-jude"],"related":[],"cancers":["medulloblastoma"],"sections":[],"technologies":["methylation-profiling","proton-therapy"],"targets":[],"drugs":[],"companies":[],"institutions":["st-jude"],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"role":"Chair, Department of Pediatric Medicine, St. Jude Children's Research Hospital","institutionId":"st-jude","specialisms":["Medulloblastoma","Paediatric neuro-oncology","Risk-adapted therapy","Molecular stratification"],"profiles":[{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Gajjar%20A%5BAuthor%5D%20medulloblastoma"}],"papers":[{"title":"Risk-adapted craniospinal radiotherapy followed by high-dose chemotherapy and stem-cell rescue in children with newly diagnosed medulloblastoma (St Jude Medulloblastoma-96)","journal":"Lancet Oncology","year":2006,"doi":"10.1016/S1470-2045(06)70867-1"},{"title":"Outcomes by clinical and molecular features in children with medulloblastoma treated with risk-adapted therapy: results of an international phase III trial (SJMB03)","journal":"JCO","year":2021,"doi":"10.1200/JCO.20.01372"}],"orcid":"0000-0001-5019-0699"},"route":"/people/amar-gajjar/","neighbours":{"cancer":[{"id":"medulloblastoma","kind":"cancer","name":"Medulloblastoma","route":"/cancers/medulloblastoma/"}],"technology":[{"id":"methylation-profiling","kind":"technology","name":"DNA methylation profiling","route":"/technologies/methylation-profiling/"},{"id":"proton-therapy","kind":"technology","name":"Proton therapy","route":"/technologies/proton-therapy/"}],"institution":[{"id":"st-jude","kind":"institution","name":"St. Jude Children's Research Hospital","route":"/institutions/st-jude/"}]}}