{"entity":{"id":"alphagenome","kind":"technology","name":"AlphaGenome","aka":[],"tldr":"Reads a million letters of DNA at once and predicts how a mutation changes gene regulation, splicing and chromatin.","summary":"AlphaGenome is Google DeepMind's long-context sequence model with multi-task regulatory heads, which reads up to a million bases of DNA and predicts, at single-base resolution, how variants change gene expression, splicing, chromatin accessibility and other regulatory signals in one model. It launched as a preview API in June 2025, and the Nature paper followed in January 2026. By unifying tasks that previously needed separate models it is relevant to interpreting non-coding cancer drivers in enhancers, promoters and splice sites. It is for research use, and cancer-specific validation is ongoing, so its predictions remain hypotheses to test rather than clinical evidence. For a newcomer: AlphaGenome reads long stretches of DNA and predicts how a mutation outside a gene would change the gene's behaviour.","status":"emerging","asOf":"2026-09-08","links":[{"label":"DeepMind AlphaGenome","url":"https://deepmind.google/discover/blog/alphagenome-ai-for-better-understanding-the-genome/"}],"tags":["foundation-model","genome"],"related":[],"cancers":[],"sections":["ai-computation"],"technologies":[],"targets":[],"drugs":[],"companies":["google-deepmind"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"principle":"Long-context sequence model with multi-task regulatory heads.","strengths":["Breadth of predicted modalities"],"limitations":["Research use; cancer-specific validation ongoing"],"since":2025},"route":"/technologies/alphagenome/","neighbours":{"section":[{"id":"ai-computation","kind":"section","name":"AI & Computation","route":"/fronts/ai-computation/"}],"company":[{"id":"google-deepmind","kind":"company","name":"Google DeepMind (and Google Research)","route":"/companies/google-deepmind/"}]}}