{"entity":{"id":"ak119","kind":"drug","name":"AK119","aka":[],"tldr":"AK119 is an experimental monoclonal antibody from Akeso in phase 2 trials for colorectal cancer, aimed at CD73 / adenosine axis.","summary":"AK119 is a monoclonal antibody developed by Akeso. Its target is CD73 / adenosine axis (the sponsor names CD73). The sponsor states: AK119 is an anti-CD73 monoclonal antibody, studied in combination with AK112 for advanced solid tumours and colorectal cancer. ClinicalTrials.gov describes the intervention as: AK119 is an anti-CD73 monoclonal antibody. It is the investigational product in 2 recruiting or active industry-led phase 2 and phase 3 interventional cancer trials, in colorectal cancer. The largest, NCT05846867, plans to enrol 170 participants with primary completion was scheduled for 2026-05-08 on the registry. Status reflects the highest phase registered on ClinicalTrials.gov; no efficacy results are recorded here.","status":"phase-2","asOf":"2026-09-11","links":[{"label":"ClinicalTrials.gov: trials of AK119","url":"https://clinicaltrials.gov/search?intr=AK119"}],"tags":["pipeline","ctgov-ingest"],"related":[],"cancers":["colorectal"],"sections":[],"technologies":[],"targets":["cd73-adenosine"],"drugs":[],"companies":["akeso"],"institutions":[],"pathways":[],"terms":[],"trials":["nct05846867","nct05689853"],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"provenance":{"editedBy":"OnCo ingestion (ClinicalTrials.gov v2 + sponsor pipeline pages)","editedOn":"2026-09-11"},"modality":"monoclonal antibody","mechanism":"AK119 is an anti-CD73 monoclonal antibody, studied in combination with AK112 for advanced solid tumours and colorectal cancer.","approvals":[],"mechanismSteps":[],"toxicity":[],"access":[],"regulatoryEvents":[]},"route":"/drugs/ak119/","neighbours":{"cancer":[{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"}],"target":[{"id":"cd73-adenosine","kind":"target","name":"CD73 / adenosine axis","route":"/targets/cd73-adenosine/"}],"company":[{"id":"akeso","kind":"company","name":"Akeso","route":"/companies/akeso/"}],"trial":[{"id":"nct05846867","kind":"trial","name":"A Phase Ib/II Clinical Study on AK112 Combined or Not Combined With AK119 in pMMR/MSS Colorectal Cancer","route":"/trials/nct05846867/"},{"id":"nct05689853","kind":"trial","name":"Study of AK119 Combined With AK112 in Patients With Advanced Solid Tumors","route":"/trials/nct05689853/"}]}}