{"entity":{"id":"aimery-de-gramont","kind":"person","name":"Aimery de Gramont","aka":[],"tldr":"Invented the FOLFOX regimen that anchors colorectal chemotherapy and founded the GERCOR and ARCAD trial groups.","summary":"Aimery de Gramont (Paris) designed the infusional fluorouracil and oxaliplatin regimen known as FOLFOX, showed its benefit in the pivotal 2000 trial, and co-led MOSAIC and the IDEA collaboration on adjuvant duration. He founded the GERCOR cooperative group and the ARCAD database of pooled colorectal trials, which has reshaped endpoints and trial design in the disease.","asOf":"2026-09-10","links":[{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=de%20Gramont%20A%5BAuthor%5D%20oxaliplatin%20colorectal"}],"tags":["colorectal","chemotherapy","cooperative-group"],"related":[],"cancers":["colorectal"],"sections":[],"technologies":["cytotoxic-chemotherapy","platinum"],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"role":"Head of Medical Oncology, Institut Hospitalier Franco-Britannique; Founder, GERCOR and ARCAD","specialisms":["Colorectal cancer","Chemotherapy regimens","Adjuvant therapy","Meta-analysis"],"profiles":[{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=de%20Gramont%20A%5BAuthor%5D%20oxaliplatin%20colorectal"}],"papers":[{"title":"Leucovorin and fluorouracil with or without oxaliplatin as first-line treatment in advanced colorectal cancer","journal":"JCO","year":2000,"doi":"10.1200/JCO.2000.18.16.2938"},{"title":"Duration of adjuvant chemotherapy for stage III colon cancer (IDEA)","journal":"NEJM","year":2018,"doi":"10.1056/NEJMoa1713709"}]},"route":"/people/aimery-de-gramont/","neighbours":{"cancer":[{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"}],"technology":[{"id":"cytotoxic-chemotherapy","kind":"technology","name":"Cytotoxic chemotherapy","route":"/technologies/cytotoxic-chemotherapy/"},{"id":"platinum","kind":"technology","name":"Platinum agents","route":"/technologies/platinum/"}],"paper":[{"id":"paper-mosaic-oxaliplatin-adjuvant-colon-nejm-2004","kind":"paper","name":"Oxaliplatin, fluorouracil, and leucovorin as adjuvant treatment for colon cancer (MOSAIC)","route":"/key-papers/paper-mosaic-oxaliplatin-adjuvant-colon-nejm-2004/"}]}}