{"entity":{"id":"agr2","kind":"target","name":"AGR2","aka":["anterior gradient 2, protein disulphide isomerase family member","Anterior gradient protein 2 homolog","XAG-2","HAG-2","AG2","PDIA17"],"tldr":"AGR2 (Anterior gradient protein 2 homolog) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Breast cancer.","summary":"Required for MUC2 post-transcriptional synthesis and secretion. May play a role in the production of mucus by intestinal cells. Proto-oncogene that may play a role in cell migration, cell differentiation and cell growth.\n\nCIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Tamoxifen.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:328","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:328"},{"label":"UniProt O95994","url":"https://www.uniprot.org/uniprotkb/O95994/entry"},{"label":"NCBI Gene 10551","url":"https://www.ncbi.nlm.nih.gov/gene/10551"},{"label":"Ensembl ENSG00000106541","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000106541"}],"tags":["cancer-genes-wave"],"related":["civic"],"cancers":["breast-cancer"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 1 therapies; CIViC holds 1 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"AGR2","role":["drug-target","biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:328","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:328","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt O95994","url":"https://www.uniprot.org/uniprotkb/O95994/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene AGR2","url":"https://civicdb.org/features/8407","note":"1 evidence items, 0 assertions, 1 variants; diseases: Breast Cancer (GraphQL API, CC0)"}],"distribution":"one-type","specificityNote":"Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the roles drug-target, biomarker; HPA finds the RNA tissue enhanced, which says where the protein sits but not whether the tumour differs from normal tissue. HPA AGR2: RNA tissue enhanced (cervix 600 nTPM, intestine 1,148 nTPM, stomach 1 1,324 nTPM); high antibody staining in 18 normal tissues; highest cancer staining stomach cancer (12 of 12 high). Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Breast cancer (all types)); Open Targets associates it with 0 specific cancer types at or above 0.5. (No rule of scripts/fetch-target-specificity.ts fired.)","specificitySources":[{"label":"Human Protein Atlas AGR2 tissue","url":"https://www.proteinatlas.org/ENSG00000106541-AGR2/tissue","note":"RNA tissue and blood lineage specificity, normal tissue antibody staining (version 25.1, CC BY-SA 3.0)"},{"label":"Open Targets ENSG00000106541 associations","url":"https://platform.opentargets.org/target/ENSG00000106541/associations","note":"cancer associations at or above 0.5 (CC0)"}],"hgnc":"HGNC:328","ensembl":"ENSG00000106541","uniprot":"O95994","entrez":"10551","firstDescribed":1998,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: Thompson D.A. et al, Biochem. Biophys. Res. Commun, 1998, \"hAG-2, the human homologue of the Xenopus laevis cement gland gene XAG-2, is coexpressed with estrogen receptor in breast cancer cell lines\".","firstDescribedSource":"https://pubmed.ncbi.nlm.nih.gov/9790916/","biology":"Required for MUC2 post-transcriptional synthesis and secretion. May play a role in the production of mucus by intestinal cells. Proto-oncogene that may play a role in cell migration, cell differentiation and cell growth. Promotes cell adhesion. Location: Secreted; Endoplasmic reticulum (UniProt). Locus 7p21.1 (HGNC).","whereFound":["Breast cancer: CIViC evidence names this disease"],"targetClass":"other","prevalence":[]},"route":"/targets/agr2/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"}],"cancer":[{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"}]}}