{"entity":{"id":"adi-peg20","kind":"drug","name":"ADI-PEG20","aka":["pegargiminase"],"tldr":"ADI-PEG20 is an experimental investigational agent whose form is not stated in the registry from Polaris in phase 3 trials for hepatocellular carcinoma, with its target not yet stated publicly.","summary":"ADI-PEG20 (PEG20) is an investigational agent whose form is not stated in the registry developed by Polaris. Its molecular target is not stated in the ClinicalTrials.gov intervention record, and OnCo has not confirmed one from the sponsor's pipeline page. It is the investigational product in 1 recruiting or active industry-led phase 2 and phase 3 interventional cancer trial, including the phase 3 study NCT05317819 (Study of ADI-PEG 20 Versus Placebo in Subjects With High Arginine Level and Unresectable Hepatocellular Carcinoma), in hepatocellular carcinoma. The largest, NCT05317819, plans to enrol 300 participants with primary completion expected 2028-09. Status reflects the highest phase registered on ClinicalTrials.gov; no efficacy results are recorded here.","status":"phase-3","asOf":"2026-09-11","links":[{"label":"ClinicalTrials.gov: trials of ADI-PEG20","url":"https://clinicaltrials.gov/search?intr=PEG20"},{"label":"Sponsor page","url":"https://www.polarispharma.com"}],"tags":["pipeline","ctgov-ingest"],"related":[],"cancers":["hcc"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":["polaris-group"],"institutions":[],"pathways":[],"terms":[],"trials":["nct05317819"],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"provenance":{"editedBy":"OnCo ingestion (ClinicalTrials.gov v2 + sponsor pipeline pages)","editedOn":"2026-09-11"},"code":"PEG20","modality":"PEGylated enzyme (pegargiminase, arginine deiminase; INN stem -ase; form not stated in the registry record)","mechanism":"Mechanism not stated in the ClinicalTrials.gov record or on the sponsor's pipeline page.","approvals":[],"mechanismSteps":[],"toxicity":[],"access":[],"regulatoryEvents":[]},"route":"/drugs/adi-peg20/","neighbours":{"cancer":[{"id":"hcc","kind":"cancer","name":"Hepatocellular carcinoma","route":"/cancers/hcc/"}],"company":[{"id":"polaris-group","kind":"company","name":"Polaris Group","route":"/companies/polaris-group/"}],"trial":[{"id":"nct05317819","kind":"trial","name":"Study of ADI-PEG 20 Versus Placebo in Subjects With High Arginine Level and Unresectable Hepatocellular Carcinoma","route":"/trials/nct05317819/"}]}}