{"entity":{"id":"adc-therapeutics","kind":"company","name":"ADC Therapeutics","aka":["ADC Therapeutics S.A.","ADC Therapeutics SA"],"tldr":"ADC Therapeutics, based in Lausanne, developed Zynlonta (loncastuximab tesirine), an antibody-drug conjugate built on its pyrrolobenzodiazepine payload platform and approved in diffuse large B-cell lymphoma. It is now switching to exatecan-based payloads, so its future rests on changing platform while staying independent.","summary":"ADC Therapeutics, based in Lausanne and listed as ADCT, developed Zynlonta, or loncastuximab tesirine, and the pyrrolobenzodiazepine payload platform behind it. Loncastuximab is approved in diffuse large B-cell lymphoma, the LOTIS-5 and LOTIS-7 trials test it in combinations, and the company is moving to exatecan-based next-generation ADCs. OnCo links it to diffuse large B-cell lymphoma and to the loncastuximab tesirine drug record. Whether a company built on one payload can change platform and stay independent is the open question. Loncastuximab tesirine has its own page.","asOf":"2026-09-04","links":[{"label":"Official website","url":"https://adctherapeutics.com"}],"tags":[],"related":[],"cancers":[],"sections":["adcs"],"technologies":[],"targets":[],"drugs":["zynlonta"],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":["nct04384484"],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"hq":"Lausanne","country":"CH","companyType":"biotech","website":"https://adctherapeutics.com","ticker":"ADCT","investors":[],"funding":[]},"route":"/companies/adc-therapeutics/","neighbours":{"section":[{"id":"adcs","kind":"section","name":"Antibody-Drug Conjugates","route":"/fronts/adcs/"}],"drug":[{"id":"zynlonta","kind":"drug","name":"Loncastuximab tesirine","route":"/drugs/zynlonta/"}],"trial":[{"id":"nct04384484","kind":"trial","name":"Study to Evaluate Loncastuximab Tesirine With Rituximab Versus Immunochemotherapy in Participants With Relapsed or Refractory Diffuse Large B-Cell Lym","route":"/trials/nct04384484/"}],"cancer":[{"id":"dlbcl","kind":"cancer","name":"Diffuse large B-cell lymphoma","route":"/cancers/dlbcl/"}],"company":[{"id":"sobi","kind":"company","name":"Sobi (Swedish Orphan Biovitrum)","route":"/companies/sobi/"}]}}