{"entity":{"id":"actrec","kind":"institution","name":"Advanced Centre for Treatment, Research and Education in Cancer","aka":["ACTREC","Tata Memorial Centre ACTREC"],"tldr":"The research and development campus of Tata Memorial Centre, where India's first indigenous CAR-T therapy was developed and low-cost trials are designed.","summary":"ACTREC opened in Kharghar, Navi Mumbai, in 2002 as the research wing of Tata Memorial Centre, combining basic science laboratories, a clinical research centre and a hospital that has since expanded into a large cancer hospital with bone marrow transplant, proton and paediatric services. Its scientists, with IIT Bombay and ImmunoACT, developed talicabtagene autoleucel (NexCAR19), India's first approved CD19 CAR-T therapy, and ACTREC hosts the Tata Memorial biobank, genomics and proteomics facilities and the Clinical Research Secretariat that ran the low-dose nivolumab and metronomic chemotherapy trials. The campus also houses the Homi Bhabha National Institute's cancer biology PhD programme and an early-phase trial unit.","asOf":"2026-09-09","links":[{"label":"ACTREC","url":"https://actrec.gov.in"},{"label":"Tata Memorial Centre","url":"https://tmc.gov.in"},{"label":"PTCOG: particle therapy facilities in operation","url":"https://www.ptcog.site/index.php/facilities-in-operation-public"}],"tags":[],"related":["global-oncology-access","point-of-care-cell-manufacturing"],"cancers":["all-leukemia","dlbcl","head-and-neck","cervical"],"sections":["cell-therapy","drug-discovery"],"technologies":["car-t","proton-therapy","proton-therapy-systems"],"targets":["cd19"],"drugs":["nivolumab"],"companies":[],"institutions":["tata-memorial"],"pathways":[],"terms":[],"trials":[],"people":["gupta-sudeep","badwe-rajendra","patil-vijay","prabhash-kumar","chaturvedi-pankaj"],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"city":"Navi Mumbai","country":"IN","lat":19.061,"lng":73.02,"institutionType":"research-institute","website":"https://actrec.gov.in","university":"Homi Bhabha National Institute","programs":["Indigenous CAR-T (NexCAR19)","Clinical Research Secretariat","Cancer biology laboratories","Bone marrow transplant"]},"route":"/institutions/actrec/","neighbours":{"technology":[{"id":"car-t","kind":"technology","name":"CAR-T cell therapy","route":"/technologies/car-t/"},{"id":"global-oncology-access","kind":"technology","name":"Global oncology and access in low- and middle-income countries","route":"/technologies/global-oncology-access/"},{"id":"point-of-care-cell-manufacturing","kind":"technology","name":"Point-of-care and decentralised cell manufacturing","route":"/technologies/point-of-care-cell-manufacturing/"},{"id":"proton-therapy","kind":"technology","name":"Proton therapy","route":"/technologies/proton-therapy/"},{"id":"proton-therapy-systems","kind":"technology","name":"Proton therapy machines: cyclotrons, synchrotrons and single-room systems","route":"/technologies/proton-therapy-systems/"}],"cancer":[{"id":"all-leukemia","kind":"cancer","name":"Acute lymphoblastic leukaemia","route":"/cancers/all-leukemia/"},{"id":"buccal-mucosa-cancer","kind":"cancer","name":"Buccal mucosa and gingivobuccal cancer (oral cancer in India)","route":"/cancers/buccal-mucosa-cancer/"},{"id":"cervical","kind":"cancer","name":"Cervical cancer","route":"/cancers/cervical/"},{"id":"dlbcl","kind":"cancer","name":"Diffuse large B-cell lymphoma","route":"/cancers/dlbcl/"},{"id":"head-and-neck","kind":"cancer","name":"Head and neck squamous cell carcinoma","route":"/cancers/head-and-neck/"}],"section":[{"id":"cell-therapy","kind":"section","name":"Cell Therapy","route":"/fronts/cell-therapy/"},{"id":"drug-discovery","kind":"section","name":"Drug Discovery Platforms","route":"/fronts/drug-discovery/"}],"target":[{"id":"cd19","kind":"target","name":"CD19","route":"/targets/cd19/"}],"drug":[{"id":"nivolumab","kind":"drug","name":"Nivolumab","route":"/drugs/nivolumab/"},{"id":"talicabtagene-autoleucel","kind":"drug","name":"Talicabtagene autoleucel","route":"/drugs/talicabtagene-autoleucel/"}],"institution":[{"id":"iit-bombay","kind":"institution","name":"Indian Institute of Technology Bombay","route":"/institutions/iit-bombay/"},{"id":"national-cancer-grid","kind":"institution","name":"National Cancer Grid of India","route":"/institutions/national-cancer-grid/"},{"id":"tata-memorial","kind":"institution","name":"Tata Memorial Centre","route":"/institutions/tata-memorial/"}],"person":[{"id":"prabhash-kumar","kind":"person","name":"Kumar Prabhash","route":"/people/prabhash-kumar/"},{"id":"chaturvedi-pankaj","kind":"person","name":"Pankaj Chaturvedi","route":"/people/chaturvedi-pankaj/"},{"id":"badwe-rajendra","kind":"person","name":"Rajendra Badwe","route":"/people/badwe-rajendra/"},{"id":"gupta-sudeep","kind":"person","name":"Sudeep Gupta","route":"/people/gupta-sudeep/"},{"id":"patil-vijay","kind":"person","name":"Vijay Patil","route":"/people/patil-vijay/"}],"company":[{"id":"immunoact","kind":"company","name":"ImmunoACT","route":"/companies/immunoact/"}],"trial":[{"id":"talicel-phase-1-2","kind":"trial","name":"Talicabtagene autoleucel (NexCAR19) phase 1/2","route":"/trials/talicel-phase-1-2/"}]}}