{"entity":{"id":"accelerate-platform","kind":"institution","name":"ACCELERATE","aka":["ACCELERATE platform","ACCELERATE Paediatric Oncology Platform"],"tldr":"ACCELERATE is a Brussels-based forum where children's cancer doctors, drug companies, the EMA and FDA and parents agree which new cancer drugs should be tested in children and how, so that medicines developed for adults are not left untested in childhood cancers.","summary":"Founded in 2013 as a joint initiative of SIOP Europe, ITCC, the European Society for Paediatric Oncology's parent groups and industry, ACCELERATE is a multi-stakeholder platform for paediatric oncology drug development. Its Paediatric Strategy Forums, held with the EMA and the FDA Oncology Center of Excellence, take a mechanism of action (ALK, MEK, BCL2, CDK4/6, ADCs, immunotherapy, radiopharmaceuticals) and agree which products should advance in children and how, an approach that feeds directly into RACE Act and EU Paediatric Regulation obligations. Other workstreams are Fit-for-Filing (making academic trial data acceptable for regulatory submissions), the Long-Term Follow-Up initiative for children on novel agents, the ACCELERATE Paediatric Oncology Master Protocol concept, and the Paediatric Oncology Preclinical Proof-of-Concept programme.","asOf":"2026-09-10","links":[{"label":"ACCELERATE","url":"https://www.accelerate-platform.org"},{"label":"Paediatric Strategy Forums","url":"https://www.accelerate-platform.org/paediatric-strategy-forums/"}],"tags":["nci-coverage","paediatric"],"related":[],"cancers":["neuroblastoma","dipg-dmg","paediatric-low-grade-glioma","all-leukemia"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":["itcc"],"institutions":["siop-europe","ema","fda-oce"],"pathways":[],"terms":["race-for-children-act"],"trials":[],"people":["nicole-scobie"],"bottlenecks":["b-rare-cancers","b-incentive-misalignment","b-regulatory-fragmentation"],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"city":"Brussels","country":"BE","lat":50.85,"lng":4.352,"institutionType":"consortium","website":"https://www.accelerate-platform.org","programs":["Paediatric Strategy Forums (with EMA and FDA)","Fit-for-Filing","Long-Term Follow-Up of children on novel agents","Pediatric Oncology Preclinical Proof-of-Concept","Annual ACCELERATE conference"]},"route":"/institutions/accelerate-platform/","neighbours":{"cancer":[{"id":"all-leukemia","kind":"cancer","name":"Acute lymphoblastic leukaemia","route":"/cancers/all-leukemia/"},{"id":"dipg-dmg","kind":"cancer","name":"Diffuse midline glioma, H3 K27-altered (including DIPG)","route":"/cancers/dipg-dmg/"},{"id":"neuroblastoma","kind":"cancer","name":"Neuroblastoma (paediatric)","route":"/cancers/neuroblastoma/"},{"id":"paediatric-low-grade-glioma","kind":"cancer","name":"Paediatric low-grade glioma","route":"/cancers/paediatric-low-grade-glioma/"}],"company":[{"id":"itcc","kind":"company","name":"Innovative Therapies for Children with Cancer (ITCC)","route":"/companies/itcc/"}],"institution":[{"id":"ema","kind":"institution","name":"European Medicines Agency","route":"/institutions/ema/"},{"id":"fda-oce","kind":"institution","name":"FDA Oncology Center of Excellence","route":"/institutions/fda-oce/"},{"id":"siop-europe","kind":"institution","name":"SIOP Europe (European Society for Paediatric Oncology)","route":"/institutions/siop-europe/"}],"term":[{"id":"race-for-children-act","kind":"term","name":"RACE for Children Act","route":"/terms/race-for-children-act/"}],"person":[{"id":"gilles-vassal","kind":"person","name":"Gilles Vassal","route":"/people/gilles-vassal/"},{"id":"nicole-scobie","kind":"person","name":"Nicole Scobie","route":"/people/nicole-scobie/"}],"bottleneck":[{"id":"b-incentive-misalignment","kind":"bottleneck","name":"Incentives reward me-too drugs and marginal gains","route":"/bottlenecks/b-incentive-misalignment/"},{"id":"b-rare-cancers","kind":"bottleneck","name":"Rare and paediatric cancers without markets","route":"/bottlenecks/b-rare-cancers/"},{"id":"b-regulatory-fragmentation","kind":"bottleneck","name":"Regulatory divergence between regions","route":"/bottlenecks/b-regulatory-fragmentation/"}],"roadmap":[{"id":"paediatric-oncology-roadmap","kind":"roadmap","name":"Paediatric oncology roadmap: cooperative-group cures → engineered immunity → drugs developed for children first","route":"/roadmaps/paediatric-oncology-roadmap/"}]}}