{"entity":{"id":"abcc3","kind":"target","name":"ABCC3","aka":["ATP binding cassette subfamily C member 3","ATP-binding cassette sub-family C member 3","MRP3","cMOAT2","EST90757","MLP2","MOAT-D"],"tldr":"ABCC3 (ATP-binding cassette sub-family C member 3) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Breast cancer.","summary":"ATP-dependent transporter of the ATP-binding cassette (ABC) family that hydrolyses ATP to enable active transport of substrates conjugated with glucuronate, glutathione or sulfate. Operates at basolateral membranes of polarised cells such as hepatocytes and intestinal epithelial cells, where it mediates the efflux of conjugated substrates from intestine and liver into the bloodstream. Involved in enterohepatic recirculation of steroid glucuronates.\n\nCIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Paclitaxel and Monomethyl Auristatin E.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:54","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:54"},{"label":"UniProt O15438","url":"https://www.uniprot.org/uniprotkb/O15438/entry"},{"label":"NCBI Gene 8714","url":"https://www.ncbi.nlm.nih.gov/gene/8714"},{"label":"Ensembl ENSG00000108846","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000108846"}],"tags":["cancer-genes-wave"],"related":["civic"],"cancers":["breast-cancer"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 2 therapies; CIViC holds 1 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"ABCC3","role":["drug-target","biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:54","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:54","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt O15438","url":"https://www.uniprot.org/uniprotkb/O15438/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene ABCC3","url":"https://civicdb.org/features/6906","note":"1 evidence items, 0 assertions, 1 variants; diseases: Breast Cancer (GraphQL API, CC0)"}],"distribution":"one-type","specificityNote":"Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the roles drug-target, biomarker; HPA finds the RNA tissue enhanced, which says where the protein sits but not whether the tumour differs from normal tissue. HPA ABCC3: RNA tissue enhanced (adrenal gland 58 nTPM, liver 49 nTPM); blood lineage lineage enriched (monocytes 6 nTPM); high antibody staining in 7 normal tissues; highest cancer staining thyroid cancer (1 of 4 high). Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Breast cancer (all types)); Open Targets associates it with 0 specific cancer types at or above 0.5. (No rule of scripts/fetch-target-specificity.ts fired.)","specificitySources":[{"label":"Human Protein Atlas ABCC3 tissue","url":"https://www.proteinatlas.org/ENSG00000108846-ABCC3/tissue","note":"RNA tissue and blood lineage specificity, normal tissue antibody staining (version 25.1, CC BY-SA 3.0)"},{"label":"Open Targets ENSG00000108846 associations","url":"https://platform.opentargets.org/target/ENSG00000108846/associations","note":"cancer associations at or above 0.5 (CC0)"}],"hgnc":"HGNC:54","ensembl":"ENSG00000108846","uniprot":"O15438","entrez":"8714","firstDescribed":1997,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: Kool et al, Cancer Res, 1997, \"Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines\".","firstDescribedSource":"https://pubmed.ncbi.nlm.nih.gov/9270026/","biology":"ATP-dependent transporter of the ATP-binding cassette (ABC) family that hydrolyses ATP to enable active transport of substrates conjugated with glucuronate, glutathione or sulfate. Operates at basolateral membranes of polarised cells such as hepatocytes and intestinal epithelial cells, where it mediates the efflux of conjugated substrates from intestine and liver into the bloodstream. Involved in enterohepatic recirculation of steroid glucuronates. Shares substrate specificity with MRP2, displaying higher affinity for both oestrogen and androgen glucuronates such as 17beta-estradiol, estrone, testosterone and 5alpha-dihydrotestosterone glucuronates. Involved in sinusoidal efflux of mono- and bis-glucuronidated bilirubin from hepatocytes into the blood for renal uptake and excretion. May selectively transport steroid sulfate conjugates. Location: Basolateral cell membrane; Basal cell membrane (UniProt). Locus 17q21.33 (HGNC).","whereFound":["Breast cancer: CIViC evidence names this disease"],"targetClass":"other","prevalence":[]},"route":"/targets/abcc3/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"}],"cancer":[{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"}]}}