{"entity":{"id":"12-de-octubre","kind":"institution","name":"Hospital Universitario 12 de Octubre","aka":["H12O","i+12 Research Institute"],"tldr":"One of Madrid's largest hospitals, a leading site for lung cancer and myeloma trials and for academic CAR-T development.","summary":"The Hospital Universitario 12 de Octubre and its research institute i+12 host the H12O-CNIO Lung Cancer Clinical Research Unit led by Luis Paz-Ares, one of the most active investigators in small-cell and non-small-cell lung cancer trials including the tarlatamab programme, and a haematology department under Joaquín Martínez-López that pioneered next-generation sequencing for minimal residual disease in myeloma and co-developed the academic BCMA CAR-T ARI-0002h with Hospital Clínic. The hospital is a major transplant centre, runs paediatric oncology and neuro-oncology services and a phase 1 unit. Its proximity to the CNIO underpins joint translational programmes.","asOf":"2026-09-09","wikipedia":"https://en.wikipedia.org/wiki/Hospital_Universitario_12_de_Octubre","links":[{"label":"Homepage","url":"https://www.comunidad.madrid/hospital/12octubre/"},{"label":"i+12","url":"https://imas12.es"}],"tags":[],"related":[],"cancers":["sclc","nsclc","multiple-myeloma","aml"],"sections":["immunotherapy","cell-therapy"],"technologies":["t-cell-engager","car-t","mrd-testing","checkpoint-inhibitor"],"targets":["dll3","bcma"],"drugs":["tarlatamab","durvalumab"],"companies":[],"institutions":["cnio","hospital-clinic-barcelona"],"pathways":[],"terms":["mrd"],"trials":[],"people":["luis-paz-ares","joaquin-martinez-lopez","carmen-martinez-de-pancorbo-gonzalez"],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"city":"Madrid","country":"ES","lat":40.375,"lng":-3.697,"institutionType":"hospital","website":"https://www.comunidad.madrid/hospital/12octubre/","university":"Universidad Complutense de Madrid","programs":["H12O-CNIO Lung Cancer Unit","Myeloma and MRD by NGS","Academic CAR-T","Transplantation","Phase 1 unit"]},"route":"/institutions/12-de-octubre/","neighbours":{"cancer":[{"id":"aml","kind":"cancer","name":"Acute myeloid leukaemia","route":"/cancers/aml/"},{"id":"multiple-myeloma","kind":"cancer","name":"Multiple myeloma","route":"/cancers/multiple-myeloma/"},{"id":"nsclc","kind":"cancer","name":"Non-small-cell lung cancer","route":"/cancers/nsclc/"},{"id":"sclc","kind":"cancer","name":"Small-cell lung cancer","route":"/cancers/sclc/"}],"section":[{"id":"cell-therapy","kind":"section","name":"Cell Therapy","route":"/fronts/cell-therapy/"},{"id":"immunotherapy","kind":"section","name":"Immunotherapy","route":"/fronts/immunotherapy/"}],"technology":[{"id":"car-t","kind":"technology","name":"CAR-T cell therapy","route":"/technologies/car-t/"},{"id":"checkpoint-inhibitor","kind":"technology","name":"Immune checkpoint inhibitors","route":"/technologies/checkpoint-inhibitor/"},{"id":"mrd-testing","kind":"technology","name":"MRD / molecular residual disease testing","route":"/technologies/mrd-testing/"},{"id":"t-cell-engager","kind":"technology","name":"T-cell engagers (bispecific)","route":"/technologies/t-cell-engager/"}],"target":[{"id":"bcma","kind":"target","name":"BCMA","route":"/targets/bcma/"},{"id":"dll3","kind":"target","name":"DLL3","route":"/targets/dll3/"}],"drug":[{"id":"durvalumab","kind":"drug","name":"Durvalumab","route":"/drugs/durvalumab/"},{"id":"tarlatamab","kind":"drug","name":"Tarlatamab","route":"/drugs/tarlatamab/"}],"institution":[{"id":"cnio","kind":"institution","name":"Centro Nacional de Investigaciones Oncológicas (CNIO)","route":"/institutions/cnio/"},{"id":"hospital-clinic-barcelona","kind":"institution","name":"Hospital Clínic de Barcelona / IDIBAPS","route":"/institutions/hospital-clinic-barcelona/"},{"id":"clinico-san-carlos","kind":"institution","name":"Hospital Clínico San Carlos","route":"/institutions/clinico-san-carlos/"},{"id":"la-princesa","kind":"institution","name":"Hospital Universitario de La Princesa","route":"/institutions/la-princesa/"},{"id":"puerta-de-hierro","kind":"institution","name":"Hospital Universitario Puerta de Hierro Majadahonda","route":"/institutions/puerta-de-hierro/"},{"id":"ramon-y-cajal","kind":"institution","name":"Hospital Universitario Ramón y Cajal","route":"/institutions/ramon-y-cajal/"}],"term":[{"id":"mrd","kind":"term","name":"Minimal / molecular residual disease (MRD)","route":"/terms/mrd/"}],"person":[{"id":"carmen-martinez-de-pancorbo-gonzalez","kind":"person","name":"Carmen Martínez de Pancorbo González","route":"/people/carmen-martinez-de-pancorbo-gonzalez/"},{"id":"joaquin-martinez-lopez","kind":"person","name":"Joaquín Martínez-López","route":"/people/joaquin-martinez-lopez/"},{"id":"luis-paz-ares","kind":"person","name":"Luis Paz-Ares","route":"/people/luis-paz-ares/"}]}}