{"id":"wrn","name":"WRN helicase (MSI-high cancers)","symbol":"WRN","route":"/targets/wrn/","asOf":"2026-09-08","xrefs":[{"hgnc":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:12791","ensembl":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000165392","uniprot":"https://www.uniprot.org/uniprotkb/Q14191/entry","alphafold-db":"https://alphafold.ebi.ac.uk/entry/Q14191","chembl":"https://www.ebi.ac.uk/chembl/explore/target/CHEMBL2146312","open-targets":"https://platform.opentargets.org/target/ENSG00000165392","civic":"https://civicdb.org/genes/7486/summary","oncokb":"https://www.oncokb.org/gene/WRN","cosmic":"https://cancer.sanger.ac.uk/cosmic/gene/analysis?ln=WRN","cbioportal":"https://www.cbioportal.org/results/mutations?cancer_study_list=msk_impact_2017&gene_list=WRN","depmap":"https://depmap.org/portal/gene/WRN?tab=overview","human-protein-atlas":"https://www.proteinatlas.org/ENSG00000165392-WRN","ncbi-gene":"https://www.ncbi.nlm.nih.gov/gene/7486","omim":"https://www.omim.org/entry/604611"}],"products":[{"id":"eik1005","name":"EIK1005","status":"phase-2","modality":"Small-molecule inhibitor","route":"/drugs/eik1005/"},{"id":"ndi-219216","name":"NDI-219216","status":"phase-2","modality":"small molecule (structure undisclosed or not yet in PubChem)","route":"/drugs/ndi-219216/"}],"trials":[{"id":"nct06898450","name":"A Study to Assess the Safety, Tolerability, and Efficacy of NDI-219216 in Patients With Advanced Solid Tumors.","nct":"NCT06898450","phase":"1/2","status":"recruiting"},{"id":"nct07262619","name":"EIK1005-002: A Clinical Research Study Evaluating EIK1005, a Werner Helicase Inhibitor, as Monotherapy and in Combination With Pembrolizumab in Partic","nct":"NCT07262619","phase":"1/2","status":"recruiting"}],"pathways":["mismatch-repair-msi","synthetic-lethality-map"],"companies":["eikon-therapeutics","nimbus-therapeutics"],"keyPapers":["paper-chan-nature","paper-depmap-tsherniak-cell-2017"],"hotspots":[],"openQuestions":[],"assays":[],"resistance":[],"licence":"CC BY-NC 4.0, attribution to OnCo (https://onco.cc); commercial use needs a licence"}