{"id":"wee1","name":"WEE1","symbol":"WEE1","route":"/targets/wee1/","asOf":"2026-09-04","xrefs":[{"hgnc":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:12761","ensembl":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000166483","uniprot":"https://www.uniprot.org/uniprotkb/P30291/entry","alphafold-db":"https://alphafold.ebi.ac.uk/entry/P30291","chembl":"https://www.ebi.ac.uk/chembl/explore/target/CHEMBL5491","open-targets":"https://platform.opentargets.org/target/ENSG00000166483","civic":"https://civicdb.org/genes/7465/summary","oncokb":"https://www.oncokb.org/gene/WEE1","cosmic":"https://cancer.sanger.ac.uk/cosmic/gene/analysis?ln=WEE1","cbioportal":"https://www.cbioportal.org/results/mutations?cancer_study_list=msk_impact_2017&gene_list=WEE1","depmap":"https://depmap.org/portal/gene/WEE1?tab=overview","human-protein-atlas":"https://www.proteinatlas.org/ENSG00000166483-WEE1","ncbi-gene":"https://www.ncbi.nlm.nih.gov/gene/7465","omim":"https://www.omim.org/entry/193525"}],"products":[{"id":"azenosertib","name":"Azenosertib","status":"phase-3","modality":"small molecule","route":"/drugs/azenosertib/"}],"trials":[{"id":"nct07546500","name":"A Study of Azenosertib (ZN-c3) Versus Investigator's Choice Chemotherapy in Subjects With Platinum-Resistant High-Grade Serous Ovarian, Primary Peritoneal, or Fallopian Tube Cancers Positive for Cyclin E1 Protein Expression","nct":"NCT07546500","phase":"3","status":"recruiting"},{"id":"nct05128825","name":"A Study of Azenosertib (ZN-c3) in Subjects With Platinum-Resistant High-Grade Serous Ovarian, Fallopian Tube or Primary Peritoneal Cancer","nct":"NCT05128825","phase":"2","status":"recruiting"}],"pathways":["circadian-control","replication-stress","p53-cell-cycle","synthetic-lethality-map","cell-cycle-engine-cdks"],"companies":["acrivon-therapeutics","debiopharm","zentalis-pharmaceuticals"],"keyPapers":[],"hotspots":[],"openQuestions":[],"assays":[],"resistance":[],"licence":"CC BY-NC 4.0, attribution to OnCo (https://onco.cc); commercial use needs a licence"}