{"id":"top1","name":"Topoisomerase I (TOP1)","symbol":"TOP1","route":"/targets/top1/","asOf":"2026-09-04","xrefs":[{"hgnc":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11986","ensembl":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000198900","uniprot":"https://www.uniprot.org/uniprotkb/P11387/entry","alphafold-db":"https://alphafold.ebi.ac.uk/entry/P11387","chembl":"https://www.ebi.ac.uk/chembl/explore/target/CHEMBL1781","open-targets":"https://platform.opentargets.org/target/ENSG00000198900","civic":"https://civicdb.org/genes/7150/summary","oncokb":"https://www.oncokb.org/gene/TOP1","cosmic":"https://cancer.sanger.ac.uk/cosmic/gene/analysis?ln=TOP1","cbioportal":"https://www.cbioportal.org/results/mutations?cancer_study_list=msk_impact_2017&gene_list=TOP1","depmap":"https://depmap.org/portal/gene/TOP1?tab=overview","human-protein-atlas":"https://www.proteinatlas.org/ENSG00000198900-TOP1","ncbi-gene":"https://www.ncbi.nlm.nih.gov/gene/7150","omim":"https://www.omim.org/entry/126420"}],"products":[{"id":"hr070803","name":"HR070803","status":"phase-3","modality":"small molecule","route":"/drugs/hr070803/"}],"trials":[{"id":"nct05945901","name":"A Phase II/III Study of HR070803 in Combination With Oxaliplatin, 5-fluorouracil, Calcium Folinate and Bevacizumab Versus FOLFOX in Combination With Bevacizumab for First-line Treatment of Advanced Colorectal Cancer","nct":"NCT05945901","phase":"2/3","status":"active"},{"id":"nct06797999","name":"First-in-Human Study of ADCE-D01 in Soft Tissue Sarcoma","nct":"NCT06797999","phase":"1/2","status":"recruiting"}],"pathways":[],"companies":["hengrui"],"keyPapers":[],"hotspots":[],"openQuestions":[],"assays":[],"resistance":[],"licence":"CC BY-NC 4.0, attribution to OnCo (https://onco.cc); commercial use needs a licence"}