{"id":"tlr7","name":"Toll-like receptor 7 (TLR7)","symbol":"TLR7","route":"/targets/tlr7/","asOf":"2026-09-04","xrefs":[{"hgnc":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:15631","ensembl":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000196664","uniprot":"https://www.uniprot.org/uniprotkb/Q9NYK1/entry","alphafold-db":"https://alphafold.ebi.ac.uk/entry/Q9NYK1","chembl":"https://www.ebi.ac.uk/chembl/explore/target/CHEMBL5936","open-targets":"https://platform.opentargets.org/target/ENSG00000196664","civic":"https://civicdb.org/genes/51284/summary","oncokb":"https://www.oncokb.org/gene/TLR7","cosmic":"https://cancer.sanger.ac.uk/cosmic/gene/analysis?ln=TLR7","cbioportal":"https://www.cbioportal.org/results/mutations?cancer_study_list=msk_impact_2017&gene_list=TLR7","depmap":"https://depmap.org/portal/gene/TLR7?tab=overview","human-protein-atlas":"https://www.proteinatlas.org/ENSG00000196664-TLR7","ncbi-gene":"https://www.ncbi.nlm.nih.gov/gene/51284","omim":"https://www.omim.org/entry/300365"}],"products":[{"id":"imiquimod","name":"Imiquimod","status":"approved","modality":"Topical immune response modifier (TLR7 agonist)","route":"/drugs/imiquimod/"}],"trials":[{"id":"scin-trial","name":"SCIN (curettage then imiquimod against excision for nodular basal cell carcinoma)","nct":"NCT02242929","phase":"3","status":"negative"},{"id":"anchor","name":"ANCHOR","nct":"NCT02135419","phase":"3","status":"positive"},{"id":"mal-pdt-imiquimod-fluorouracil-superficial-bcc","name":"Photodynamic therapy against imiquimod against fluorouracil for superficial basal cell carcinoma","nct":"ISRCTN79701845","phase":"3","status":"positive"},{"id":"sins-trial","name":"SINS (surgical excision against imiquimod cream for basal cell carcinoma)","nct":"ISRCTN48755084","phase":"3","status":"negative"},{"id":"nct07605962","name":"Phase 1/2 Study of UI-102 in Selected Advanced Cancers","nct":"NCT07605962","phase":"1/2","status":"recruiting"}],"pathways":[],"companies":["bausch-health"],"keyPapers":[],"hotspots":[],"openQuestions":[],"assays":[],"resistance":[],"licence":"CC BY-NC 4.0, attribution to OnCo (https://onco.cc); commercial use needs a licence"}