{"id":"smad4","name":"SMAD4","symbol":"SMAD4","route":"/targets/smad4/","asOf":"2026-09-23","xrefs":[{"hgnc":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6770","ensembl":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000141646","uniprot":"https://www.uniprot.org/uniprotkb/Q13485/entry","alphafold-db":"https://alphafold.ebi.ac.uk/entry/Q13485","open-targets":"https://platform.opentargets.org/target/ENSG00000141646","civic":"https://civicdb.org/genes/4089/summary","oncokb":"https://www.oncokb.org/gene/SMAD4","cosmic":"https://cancer.sanger.ac.uk/cosmic/gene/analysis?ln=SMAD4","cbioportal":"https://www.cbioportal.org/results/mutations?cancer_study_list=msk_impact_2017&gene_list=SMAD4","depmap":"https://depmap.org/portal/gene/SMAD4?tab=overview","human-protein-atlas":"https://www.proteinatlas.org/ENSG00000141646-SMAD4","ncbi-gene":"https://www.ncbi.nlm.nih.gov/gene/4089","omim":"https://www.omim.org/entry/600993"}],"products":[],"trials":[],"pathways":[],"companies":[],"keyPapers":["paper-cowzer-biliary-targeted-therapy-determinants-ccr-2026","paper-suryavanshi-indian-gallbladder-genomics-jco-go-2025","paper-zhu-population-specific-immunogenomics-gallbladder-cancer-mod-pathol-2025","paper-giraldo-gallbladder-msk-impact-ccr-2022","paper-noe-cyst-malignant-progression-genomics-nat-commun-2020","paper-omori-ipmn-progression-pathways-gastroenterology-2019","paper-singhi-targeted-genome-profiling-3594-pdac-gastroenterology-2019","paper-narayan-gallbladder-regional-mutations-cancer-2019","paper-qian-driver-genes-outcomes-resected-pancreatic-jama-oncol-2018","paper-loree-tumour-location-continuum-colorectal-ccr-2018","paper-yaeger-metastatic-colorectal-genomic-landscape-cancer-cell-2018","paper-wardell-biliary-drivers-germline-j-hepatol-2018","paper-felsenstein-ipmn-cooccurring-cancer-relatedness-gut-2018","paper-tauriello-tgfbeta-immune-evasion-colorectal-nature-2018","paper-tcga-pancreatic-integrated-characterisation-cancer-cell-2017","paper-notta-punctuated-evolution-pancreatic-nature-2016","paper-javle-biliary-ngs-cancer-2016","paper-bailey-molecular-subtypes-pancreatic-nature-2016","paper-springer-pancreatic-cyst-molecular-classification-gastroenterology-2015","paper-waddell-whole-genomes-pancreatic-nature-2015","paper-tcga-colorectal-comprehensive-characterization-nature-2012","paper-biankin-pancreatic-exomes-axon-guidance-nature-2012","paper-crane-smad4-progression-pattern-locally-advanced-jco-2011","paper-iacobuzio-donahue-dpc4-failure-pattern-autopsy-jco-2009","paper-jones-pancreatic-core-pathways-science-2008","paper-fearon-cell","paper-vogelstein-genetic-alterations-colorectal-tumor-development-nejm-1988"],"hotspots":[],"openQuestions":[],"assays":[],"resistance":[],"licence":"CC BY-NC 4.0, attribution to OnCo (https://onco.cc); commercial use needs a licence"}