{"id":"shp2","name":"SHP2 (PTPN11)","symbol":"PTPN11","route":"/targets/shp2/","asOf":"2026-09-22","xrefs":[{"hgnc":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9644","ensembl":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000179295","uniprot":"https://www.uniprot.org/uniprotkb/Q06124/entry","alphafold-db":"https://alphafold.ebi.ac.uk/entry/Q06124","chembl":"https://www.ebi.ac.uk/chembl/explore/target/CHEMBL3864","open-targets":"https://platform.opentargets.org/target/ENSG00000179295","civic":"https://civicdb.org/genes/5781/summary","oncokb":"https://www.oncokb.org/gene/PTPN11","cosmic":"https://cancer.sanger.ac.uk/cosmic/gene/analysis?ln=PTPN11","cbioportal":"https://www.cbioportal.org/results/mutations?cancer_study_list=msk_impact_2017&gene_list=PTPN11","depmap":"https://depmap.org/portal/gene/PTPN11?tab=overview","human-protein-atlas":"https://www.proteinatlas.org/ENSG00000179295-PTPN11","ncbi-gene":"https://www.ncbi.nlm.nih.gov/gene/5781","omim":"https://www.omim.org/entry/176876"}],"products":[{"id":"sitneprotafib","name":"Sitneprotafib","status":"phase-3","modality":"small molecule","route":"/drugs/sitneprotafib/"}],"trials":[{"id":"nct06416410","name":"JAB-21822 Combined With JAB-3312 Compared SOC in the First Line for Treatment of Advanced Non-small Cell Lung Cancer With KRAS p.G12C Mutation","nct":"NCT06416410","phase":"3","status":"recruiting"},{"id":"nct05288205","name":"Phase 1/2a Study of JAB-21822 Plus JAB-3312 in Patients With Advanced Solid Tumors Harboring KRAS p.G12C Mutation","nct":"NCT05288205","phase":"1/2","status":"recruiting"}],"pathways":[],"companies":["allist"],"keyPapers":[],"hotspots":[],"openQuestions":[],"assays":[],"resistance":[],"licence":"CC BY-NC 4.0, attribution to OnCo (https://onco.cc); commercial use needs a licence"}