{"id":"rb1","name":"RB1","symbol":"RB1","route":"/targets/rb1/","asOf":"2026-09-23","xrefs":[{"hgnc":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9884","ensembl":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000139687","uniprot":"https://www.uniprot.org/uniprotkb/P06400/entry","alphafold-db":"https://alphafold.ebi.ac.uk/entry/P06400","open-targets":"https://platform.opentargets.org/target/ENSG00000139687","civic":"https://civicdb.org/genes/5925/summary","oncokb":"https://www.oncokb.org/gene/RB1","cosmic":"https://cancer.sanger.ac.uk/cosmic/gene/analysis?ln=RB1","cbioportal":"https://www.cbioportal.org/results/mutations?cancer_study_list=msk_impact_2017&gene_list=RB1","depmap":"https://depmap.org/portal/gene/RB1?tab=overview","human-protein-atlas":"https://www.proteinatlas.org/ENSG00000139687-RB1","ncbi-gene":"https://www.ncbi.nlm.nih.gov/gene/5925","omim":"https://www.omim.org/entry/614041"}],"products":[],"trials":[],"pathways":[],"companies":[],"keyPapers":["paper-mateo-genomics-lethal-prostate-diagnosis-castration-resistance-jci-2020","paper-offin-rb1-tp53-transformation-risk-jto-2019","paper-marcoux-egfr-small-cell-transformation-outcomes-jco-2019","paper-bertucci-metastatic-breast-genomics-nature-2019","paper-abida-genomic-correlates-outcome-mcrpc-pnas-2019","paper-chung-comprehensive-genomic-profiling-prostate-jco-po-2019","paper-bareche-tnbc-multiomic-heterogeneity-ann-oncol-2018","paper-lee-clonal-history-small-cell-transformation-jco-2017","paper-wyatt-ctdna-tissue-concordance-mcrpc-jnci-2017","paper-ku-rb1-trp53-lineage-plasticity-science-2017","paper-mu-sox2-lineage-plasticity-science-2017","paper-aparicio-aggressive-variant-prostate-tumour-suppressors-ccr-2016","paper-beltran-nepc-divergent-evolution-nat-med-2016","paper-kumar-interindividual-genomic-diversity-metastatic-prostate-nat-med-2016","paper-george-sclc-genomic-profiles-nature-2015","paper-tcga-lung-squamous-nature-2012","paper-tcga-breast-molecular-portraits-nature-2012","paper-sequist-genotypic-histological-evolution-egfr-resistance-sci-transl-med-2011","paper-herschkowitz-rb1-loss-basal-like-bcr-2008"],"hotspots":[],"openQuestions":[],"assays":[],"resistance":[],"licence":"CC BY-NC 4.0, attribution to OnCo (https://onco.cc); commercial use needs a licence"}