{"id":"rankl","name":"RANK ligand (RANKL)","symbol":"TNFSF11","route":"/targets/rankl/","asOf":"2026-09-10","xrefs":[{"hgnc":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11926","ensembl":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000120659","uniprot":"https://www.uniprot.org/uniprotkb/O14788/entry","alphafold-db":"https://alphafold.ebi.ac.uk/entry/O14788","chembl":"https://www.ebi.ac.uk/chembl/explore/target/CHEMBL2364162","open-targets":"https://platform.opentargets.org/target/ENSG00000120659","civic":"https://civicdb.org/genes/8600/summary","oncokb":"https://www.oncokb.org/gene/TNFSF11","cosmic":"https://cancer.sanger.ac.uk/cosmic/gene/analysis?ln=TNFSF11","cbioportal":"https://www.cbioportal.org/results/mutations?cancer_study_list=msk_impact_2017&gene_list=TNFSF11","depmap":"https://depmap.org/portal/gene/TNFSF11?tab=overview","human-protein-atlas":"https://www.proteinatlas.org/ENSG00000120659-TNFSF11","ncbi-gene":"https://www.ncbi.nlm.nih.gov/gene/8600","omim":"https://www.omim.org/entry/602642"}],"products":[{"id":"denosumab","name":"Denosumab","status":"approved","modality":"Monoclonal antibody (anti-RANKL, fully human IgG2)","route":"/drugs/denosumab/"}],"trials":[{"id":"peace-3","name":"PEACE-3 (EORTC 1333)","nct":"NCT02194842","phase":"3","status":"positive"},{"id":"nct07028268","name":"A Trial of SHR-2017 Injection in Patients With Bone Metastases From Solid Tumors","nct":"NCT07028268","phase":"2","status":"recruiting"}],"pathways":[],"companies":["amgen"],"keyPapers":[],"hotspots":[],"openQuestions":[],"assays":[],"resistance":[],"licence":"CC BY-NC 4.0, attribution to OnCo (https://onco.cc); commercial use needs a licence"}