{"id":"pten","name":"PTEN","symbol":"PTEN","route":"/targets/pten/","asOf":"2026-09-23","xrefs":[{"hgnc":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9588","ensembl":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000171862","uniprot":"https://www.uniprot.org/uniprotkb/P60484/entry","alphafold-db":"https://alphafold.ebi.ac.uk/entry/P60484","chembl":"https://www.ebi.ac.uk/chembl/explore/target/CHEMBL2052032","open-targets":"https://platform.opentargets.org/target/ENSG00000171862","civic":"https://civicdb.org/genes/5728/summary","oncokb":"https://www.oncokb.org/gene/PTEN","cosmic":"https://cancer.sanger.ac.uk/cosmic/gene/analysis?ln=PTEN","cbioportal":"https://www.cbioportal.org/results/mutations?cancer_study_list=msk_impact_2017&gene_list=PTEN","depmap":"https://depmap.org/portal/gene/PTEN?tab=overview","human-protein-atlas":"https://www.proteinatlas.org/ENSG00000171862-PTEN","ncbi-gene":"https://www.ncbi.nlm.nih.gov/gene/5728","omim":"https://www.omim.org/entry/601728"}],"products":[],"trials":[{"id":"nct03997123","name":"Capivasertib+Paclitaxel as First Line Treatment for Patients With Locally Advanced or Metastatic TNBC","nct":"NCT03997123","phase":"3","status":"active"},{"id":"ipatunity130","name":"IPATunity130","nct":"NCT03337724","phase":"3","status":"negative"},{"id":"imbassador250","name":"IMbassador250","nct":"NCT03016312","phase":"3","status":"negative"},{"id":"pakt","name":"PAKT","nct":"NCT02423603","phase":"2","status":"positive"},{"id":"lotus","name":"LOTUS","nct":"NCT02162719","phase":"2","status":"positive"}],"pathways":[],"companies":[],"keyPapers":["paper-stopsack-prostate-genomes-by-race-ccr-2022","paper-ipatential150-ipatasertib-abiraterone-pten-lancet-2021","paper-schmid-pakt-capivasertib-tnbc-jco-2020","paper-mateo-genomics-lethal-prostate-diagnosis-castration-resistance-jci-2020","paper-barroso-sousa-tmb-pten-ici-mtnbc-ccr-2020","paper-chung-comprehensive-genomic-profiling-prostate-jco-po-2019","paper-loree-tumour-location-continuum-colorectal-ccr-2018","paper-bareche-tnbc-multiomic-heterogeneity-ann-oncol-2018","paper-wyatt-ctdna-tissue-concordance-mcrpc-jnci-2017","paper-kim-lotus-ipatasertib-tnbc-lancet-oncol-2017","paper-ku-rb1-trp53-lineage-plasticity-science-2017","paper-aparicio-aggressive-variant-prostate-tumour-suppressors-ccr-2016","paper-george-sclc-genomic-profiles-nature-2015","paper-ferraldeschi-pten-protein-loss-abiraterone-eur-urol-2015","paper-robinson-integrative-clinical-genomics-advanced-prostate-cell-2015","paper-tcga-molecular-taxonomy-primary-prostate-cell-2015","paper-tcga-lung-squamous-nature-2012","paper-tcga-breast-molecular-portraits-nature-2012","paper-shah-tnbc-clonal-evolution-nature-2012","paper-carver-pi3k-ar-reciprocal-feedback-prostate-cancer-cell-2011"],"hotspots":[],"openQuestions":[],"assays":[],"resistance":[],"licence":"CC BY-NC 4.0, attribution to OnCo (https://onco.cc); commercial use needs a licence"}