{"id":"pole","name":"POLE","symbol":"POLE","route":"/targets/pole/","asOf":"2026-09-23","xrefs":[{"hgnc":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9177","ensembl":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000177084","uniprot":"https://www.uniprot.org/uniprotkb/Q07864/entry","alphafold-db":"https://alphafold.ebi.ac.uk/entry/Q07864","open-targets":"https://platform.opentargets.org/target/ENSG00000177084","civic":"https://civicdb.org/genes/5426/summary","oncokb":"https://www.oncokb.org/gene/POLE","cosmic":"https://cancer.sanger.ac.uk/cosmic/gene/analysis?ln=POLE","cbioportal":"https://www.cbioportal.org/results/mutations?cancer_study_list=msk_impact_2017&gene_list=POLE","depmap":"https://depmap.org/portal/gene/POLE?tab=overview","human-protein-atlas":"https://www.proteinatlas.org/ENSG00000177084-POLE","ncbi-gene":"https://www.ncbi.nlm.nih.gov/gene/5426","omim":"https://www.omim.org/entry/174762"}],"products":[],"trials":[],"pathways":[],"companies":[],"keyPapers":["paper-domingo-somatic-pole-proofreading-colorectal-lancet-gastro-2016","paper-palles-germline-pole-pold1-proofreading-nat-genet-2013"],"hotspots":[],"openQuestions":[],"assays":[],"resistance":[],"licence":"CC BY-NC 4.0, attribution to OnCo (https://onco.cc); commercial use needs a licence"}