{"id":"pdgfra","name":"PDGFRA","symbol":"PDGFRA","route":"/targets/pdgfra/","asOf":"2026-09-08","xrefs":[{"hgnc":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:8803","ensembl":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000134853","uniprot":"https://www.uniprot.org/uniprotkb/P16234/entry","alphafold-db":"https://alphafold.ebi.ac.uk/entry/P16234","chembl":"https://www.ebi.ac.uk/chembl/explore/target/CHEMBL2007","open-targets":"https://platform.opentargets.org/target/ENSG00000134853","civic":"https://civicdb.org/genes/5156/summary","oncokb":"https://www.oncokb.org/gene/PDGFRA","cosmic":"https://cancer.sanger.ac.uk/cosmic/gene/analysis?ln=PDGFRA","cbioportal":"https://www.cbioportal.org/results/mutations?cancer_study_list=msk_impact_2017&gene_list=PDGFRA","depmap":"https://depmap.org/portal/gene/PDGFRA?tab=overview","human-protein-atlas":"https://www.proteinatlas.org/ENSG00000134853-PDGFRA","ncbi-gene":"https://www.ncbi.nlm.nih.gov/gene/5156","omim":"https://www.omim.org/entry/173490"}],"products":[{"id":"chiauranib","name":"Chiauranib","status":"phase-3","modality":"small molecule","route":"/drugs/chiauranib/"}],"trials":[{"id":"nct04921527","name":"Chiauranib Plus Weekly Paclitaxel in Patients with Platinum-refractory or Platinum-resistant Recurrent Ovarian Cancer","nct":"NCT04921527","phase":"3","status":"recruiting"}],"pathways":["glioma-signalling"],"companies":["chipscreen"],"keyPapers":[],"hotspots":[{"label":"D842V (exon 18)","position":842,"kind":"activating","frequency":"About 5% of GIST","drugs":["avapritinib"]}],"openQuestions":[],"assays":[],"resistance":[],"licence":"CC BY-NC 4.0, attribution to OnCo (https://onco.cc); commercial use needs a licence"}