{"id":"palb2","name":"PALB2","symbol":"PALB2","route":"/targets/palb2/","asOf":"2026-09-23","xrefs":[{"hgnc":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:26144","ensembl":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000083093","uniprot":"https://www.uniprot.org/uniprotkb/Q86YC2/entry","alphafold-db":"https://alphafold.ebi.ac.uk/entry/Q86YC2","open-targets":"https://platform.opentargets.org/target/ENSG00000083093","civic":"https://civicdb.org/genes/79728/summary","oncokb":"https://www.oncokb.org/gene/PALB2","cosmic":"https://cancer.sanger.ac.uk/cosmic/gene/analysis?ln=PALB2","cbioportal":"https://www.cbioportal.org/results/mutations?cancer_study_list=msk_impact_2017&gene_list=PALB2","depmap":"https://depmap.org/portal/gene/PALB2?tab=overview","human-protein-atlas":"https://www.proteinatlas.org/ENSG00000083093-PALB2","ncbi-gene":"https://www.ncbi.nlm.nih.gov/gene/79728","omim":"https://www.omim.org/entry/610355"}],"products":[],"trials":[{"id":"europac","name":"EUROPAC","nct":"ISRCTN62546421","phase":"observational","status":"recruiting"}],"pathways":[],"companies":[],"keyPapers":["paper-hudson-phillips-expanded-germline-testing-clin-breast-cancer-2026","paper-reiss-rucaparib-maintenance-brca-palb2-pancreatic-jco-2021","paper-park-hrd-pancreatic-platinum-ccr-2020","paper-caps-consortium-surveillance-recommendations-gut-2020","paper-yurgelun-germline-second-hits-resected-pancreatic-genet-med-2019","paper-staaf-tnbc-whole-genome-scan-b-nat-med-2019","paper-zheng-nigerian-inherited-breast-cancer-jco-2018","paper-lowery-prospective-germline-exocrine-pancreatic-jnci-2018","paper-shimelis-tnbc-risk-genes-jnci-2018","paper-connor-mutational-signatures-immune-pancreatic-jama-oncol-2017","paper-shindo-germline-sporadic-pancreatic-jco-2017","paper-pritchard-inherited-dna-repair-metastatic-prostate-nejm-2016","paper-couch-tnbc-germline-17-genes-jco-2015","paper-waddell-whole-genomes-pancreatic-nature-2015"],"hotspots":[],"openQuestions":[],"assays":[],"resistance":[],"licence":"CC BY-NC 4.0, attribution to OnCo (https://onco.cc); commercial use needs a licence"}